ILT4/CD85d/LILRB2 Antibody (JTX-8064) [Alexa Fluor™ Plus 488] - Humanized

• Reactivity: Hu
• Applications: ELISA, Flow, Func
• Clone: JTX-8064
• Clonality: Monoclonal
• Host: Human
• Conjugate: Alexa Fluor Plus 488

ILT4/CD85d/LILRB2 Antibody (JTX-8064) [Alexa Fluor™ Plus 488] - Humanized Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: LILRB2 / ILT4 / CD85d
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Gene: LILRB2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Functional
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for ILT4/CD85d/LILRB2 Antibody (JTX-8064) [Alexa Fluor™ Plus 488] - Humanized

• CD85 antigen-like family member D
• CD85d antigen
• CD85d
• Ig-like transcript 4
• ILT4
• ILT-4
• ILT4CD85d
• Immunoglobulin-like transcript 4
• Leukocyte immunoglobulin-like receptor 2
• leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform
• leukocyte immunoglobulin-like receptor subfamily B member 2
• leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains)
• LILRB2
• LIR2
• LIR2CD85D
• LIR-2subfamily A (with TM domain), member 6
• member 2
• MIR10
• MIR10LILRA6
• Monocyte/macrophage immunoglobulin-like receptor 10

Background

LILRB2, also known as Leukocyte immunoglobulin-like receptor subfamily B member 2, has 2 isoforms, a 598 amino acid isoform that is 65 kDa and a 597 amino acid isoform that is approx. 65 kDa; expressed on monocytes and B-cells, and at lower levels on dendritic cells and in natural killer (NK) cells; as a receptor binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response; also competes with CD8A for binding to class I MHC antigens and inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Disease research is currently being performed with relation to LILRB2 and herpes simplex, chronic lymphocytic leukemia, lymphocytic leukemia, and leukemia. Interactions with this protein have been shown to involve PTPN6, FCGR1A, HLA-F, HLA-G, CD1D and other proteins in osteoclast differentiation, immune-regulatory interactions between a lymphoid and a non-lymphoid cell, adaptive immune system, and immune system pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LILRB2