ILT4/CD85d/LILRB2 Products

Description

The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR) (1-3). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC) (4). Human ILT4 is produced as a 598 amino acid (aa) precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 116 aa cytoplasmic domain. The ECD contains four Ig-like domains, and the cytoplasmic domain contains three immunoreceptor tyrosine-based inhibitory motifs (ITIM) (5). The ECD of human ILT4 shares 76% aa identity with chimpanzee ILT4 and 74%, 81%, 33%, 52%, 77%, 61%, and 64 % aa identity with human ILT1, 2, 3, 5, 6, 7, and 8, respectively. ILT4 binds to classical MHC I proteins as well as the non-classical HLA-G1 and HLA-F molecules (5-9). It competes with CD8 alpha for MHC I binding but does not compete with KIR2DL1 (7). Ligation of ILT4 induces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1 (4, 6). Activation of ILT4 inhibits signaling through Fc gamma RI (4) and Fc epsilon RI (6) and causes DC to become tolerogenic by down‑regulation of co‑stimulatory molecules (10, 11). ILT4 mediates tolerogenic DC‑induced CD4+ T cell energy in vitro and in vivo (10-12).

Bioinformatics

Uniprot	AAH36827.1
Product By Gene ID	10288
Alternate Names	CD85 antigen-like family member D CD85d antigen CD85d Ig-like transcript 4 ILT4 ILT-4 ILT4CD85d Immunoglobulin-like transcript 4 Leukocyte immunoglobulin-like receptor 2 leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform leukocyte immunoglobulin-like receptor subfamily B member 2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains) LILRB2 LIR2 LIR2CD85D LIR-2subfamily A (with TM domain), member 6 member 2 MIR10 MIR10LILRA6 Monocyte/macrophage immunoglobulin-like receptor 10