ILT4/CD85d/LILRB2 Products

Description

LILRB2, also known as Leukocyte immunoglobulin-like receptor subfamily B member 2, has 2 isoforms, a 598 amino acid isoform that is 65 kDa and a 597 amino acid isoform that is approx. 65 kDa; expressed on monocytes and B-cells, and at lower levels on dendritic cells and in natural killer (NK) cells; as a receptor binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response; also competes with CD8A for binding to class I MHC antigens and inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Disease research is currently being performed with relation to LILRB2 and herpes simplex, chronic lymphocytic leukemia, lymphocytic leukemia, and leukemia. Interactions with this protein have been shown to involve PTPN6, FCGR1A, HLA-F, HLA-G, CD1D and other proteins in osteoclast differentiation, immune-regulatory interactions between a lymphoid and a non-lymphoid cell, adaptive immune system, and immune system pathways.

Bioinformatics

Entrez	10288 Human
Uniprot	AAH36827 Human NM_005874 Human NP_005865 Human Q8N423 Human
Product By Gene ID	10288
Alternate Names	CD85 antigen-like family member D CD85d antigen Ig-like transcript 4 ILT-4 ILT4CD85d Immunoglobulin-like transcript 4 Leukocyte immunoglobulin-like receptor 2 leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform leukocyte immunoglobulin-like receptor subfamily B member 2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains) LIR2CD85D LIR-2subfamily A (with TM domain), member 6 member 2 MIR10LILRA6 Monocyte/macrophage immunoglobulin-like receptor 10