ILT3/CD85k/LILRB4 Antibody (293623) [Allophycocyanin]

Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human IL-3 Ra/CD123 PE-conjugated Monoclonal Antibody (Catalog # FAB301P) and either (A) Mouse Anti-Human LILRB4/CD85k/ILT3 APC-conjugated Monoclonal Antibody (Catalog # FAB24251A) or (B) Mouse IgG2AAllophycocyanin Isotype Control (Catalog # IC003A). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 293623
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

ILT3/CD85k/LILRB4 Antibody (293623) [Allophycocyanin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human ILT3/CD85k
  Pro17-His257
  Accession # ABM86208
• Specificity: Detects human ILT3/CD85k in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with with recombinant human (rh) ILT5 is observed. No cross-reactivity with rhILT1, rhILT2, rhILT4, rhILT7, rhILT11, rhLIR-6 or rhLIR-8 is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: LILRB4
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ILT3/CD85k/LILRB4 Antibody (293623) [Allophycocyanin]

• CD85 antigen-like family member K
• CD85k antigen
• CD85k
• HM18
• ILT3
• ILT-3
• ILT3CD85K
• leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains)
• LILRB4
• LIR5
• LIR5LILRB5
• LIR-5subfamily B, member 4
• member 4

Background

Immunoglobulin-Like Transcript 3 (ILT3), also known as Leukocyte Immunoglobulin-Like Receptor subfamily B member 4 (LILRB4) and Leukocyte Immunoglobulin-like Receptor 5 (LIR-5), is a type I membrane protein that functions as a receptor for class I MHC antigens. It contains cytoplasmic ITIM motifs and is involved in the down-regulation of immune responses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ILT3/CD85k/LILRB4 Antibody (FAB24251A)(1)

Publication using FAB24251A

• Perna F, Berman S H et al. Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML. Cancer Cell 2017-09-10 [PMID: 29017060]

Bioinformatics

• Gene Symbol: LILRB4
• Uniprot:
  • ABM86208()