Recombinant Human IL6R Protein

Product Discontinued

Recombinant Human IL6R Protein Summary

• Description: A biologically active protein to IL6R.Source: Baculovirus
• Details of Functionality: The ED50, as determined by enhancing IL-6 activity using murine M1 cells, is less than 15 ng/ml.
• Source: Baculovirus
• Protein/Peptide Type: Recombinant Protein
• Gene: IL6R
• Purity: Size Exclusion Chromatography
• Endotoxin Note: Less than 1 EU/ug of the rHuIL-6 R alpha as determined by LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • Functional
  • SDS-Page
• Theoretical MW: 37.9 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Concentration: LYOPH
• Purity: Size Exclusion Chromatography
• Reconstitution Instructions: Reconstitute with sterilized PBS or aqueous buffer to a final concentration of 0.1 mg/ml.

Alternate Names for Recombinant Human IL6R Protein

• CD126 antigen
• CD126
• gp80
• IL-6 receptor subunit alpha
• IL-6R 1
• IL-6R subunit alpha
• IL-6R-1
• IL6RA
• IL-6RA
• IL-6R-alpha
• interleukin 6 receptor alpha subunit
• interleukin 6 receptor
• interleukin-6 receptor subunit alpha
• Membrane glycoprotein 80
• MGC104991

Background

Interleukin-6 Receptor (IL-6 R) is a transmembrane receptor for the multifunctional cytokine IL-6 which plays a major role in the mediation of inflammatory and immune responses. IL-6 R binds to IL-6 with high affinity and associates with gp130/CD130 to form the signaling receptor complex. IL-6 R is primarily expressed on hepatocytes and leukocytes, while gp130 is ubiquitously expressed. gp130 also functions as a component of the receptor complexes for Cardiotrophin-1, CLC, CNTF, G-CSF, IL-11, IL-31, Leptin, LIF, Neuropoietin, and Oncostatin M. Complexes of IL-6 with naturally occurring soluble IL-6 R can bind cell surface gp130 and induce trans signaling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: IL6R