IL-36Ra/IL-1F5 Antibody (190524)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
190524
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

IL-36Ra/IL-1F5 Antibody (190524) Summary

Immunogen
E. coli-derived recombinant human IL-36Ra/IL-1F5
Met1-Asp155
Accession # Q9UBH0
Specificity
Detects human IL-36Ra/IL-1F5 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross‑react with recombinant human (rh) IL-1 alpha, rhIL-1 beta, rhIL-1ra, rhIL-18, rhIL-1F6, or rhIL-1F8.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
IL36RN
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publication using
MAB1275 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-36Ra/IL-1F5 Antibody (190524)

  • FIL1 delta
  • FIL1
  • FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta)
  • FIL1DIL-1 delta
  • IL1F5 (Canonical product IL-1F5a)
  • IL1F5
  • IL-1HY1
  • IL-1L1
  • IL-1RP3
  • IL36Ra
  • IL-36Ra
  • IL36RN
  • interleukin 1 family, member 5 (delta)
  • interleukin 1, delta
  • Interleukin 36 Receptor Antagonist
  • interleukin-1 family member 5
  • Interleukin-1 HY1
  • Interleukin-1 receptor antagonist homolog 1
  • Interleukin-1-like protein 1
  • Interleukin-36 Receptor Antagonist

Background

Human interleukin 1 family member #5 [IL-1F5; also named FIL-1δ (delta), IL-1HY1, IL-1H3, and IL-1L1] is a member of the IL-1 family of proteins (1‑5). IL-1 family members include IL-1 beta, IL-1 alpha, IL-1ra, IL-18, and IL-1F5 - IL-1F10 (6). All family members show a 12 beta -strand, beta -trefoil configuration, and all family members are believed to have arisen from a common ancestral gene that underwent multiple duplications (6). The human IL-1F5 gene is in closest proximity to the gene for IL-1ra and is likely a relatively recent duplication of the IL-1ra gene (2, 3). IL-1F5 is synthesized as a 155 amino acid (aa) protein that contains no signal sequence, no prosegment and no potential N-linked glycosylation site(s) (2‑5). Nevertheless, it appears to be secreted as a 17 kDa monomer (5). There is an alternate start site that potentially gives rise to an alternate splice form (5). The translated product, however, has a premature stop codon, resulting in a truncated 16 aa peptide. Human to mouse, full length IL-1F5 has 90% aa identity. Within the family, IL-1F5 is 50% aa identical to IL-1ra, and 32%, 31%, 35%, 37%, 32%, and 42% aa identical to IL‑1 beta, IL-1F6, F7, F8, F9, and F10, respectively. Cells reported to express IL-1F5 include monocytes, B cells, dendritic cells/Langerhans cells, keratinocytes, and gastric fundus Parietal and Chief cells (1, 7). The receptor for IL-1F5 has not been positively identified. Indirect evidence suggests it is IL-1 Rrp2 and/or IL‑1 RAcP (8). In either case, activity association with receptor binding is also unclear. It was initially reported to be an antagonist of IL-1F9 activity (4, 6). This would be consistent with its hypothesized relationship to IL-1ra. Studies, however, find IL-1F5 antagonist activity difficult to demonstrate (8).

  1. Smith, D.E. et al. (2000) J. Biol. Chem. 275:1169.
  2. Kumar, S. et al. (2000) J. Biol. Chem. 275:10308.
  3. Mulero, J.J. et al. (1999) Biochem. Biophys. Res. Commun. 263:702.
  4. Nicklin, M.J.H. et al. (2002) Genomics. 79:718.
  5. Barton, J.L. et al. (2000) Eur. J. Immunol. 30:3299.
  6. Dunn, E. et al. (2001) Trends Immunol. 22:533.
  7. Debets, R. et al. (2001) J. Immunol. 167:1440.
  8. Towne, J.E. et al. (2004) J. Biol. Chem. 279:13677.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-36Ra/IL-1F5 Antibody (MAB1275)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-Fr.


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Bioinformatics

Gene Symbol IL36RN
Uniprot