IL-36Ra/IL-1F5 Products

Description

Interleukin-36 receptor antagonist (IL-36RA) is a secreted protein which belongs to the interleukin 1 cytokine family (IL-1 family) and it is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes.IL-36RA has been reported to antagonize the biological activity of IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9). Furthermore, it could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1). In addition, The receptor for IL-36RA has not been positively identified. Indirect evidence suggests it is IL-1Rrp2. Recombinant murine interleukin-36 RA contains 154 amino acid residues and it shares 91 % a.a. sequence identity with human IL-36RA.

Bioinformatics

Uniprot	Q9UBH0 Q9UBH0 Q9UBH0
Product By Gene ID	26525
Alternate Names	FIL1 delta FIL1 FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta) FIL1DIL-1 delta IL1F5 (Canonical product IL-1F5a) IL1F5 IL-1HY1 IL-1L1 IL-1RP3 IL36Ra IL-36Ra IL36RN interleukin 1 family, member 5 (delta) interleukin 1, delta Interleukin 36 Receptor Antagonist interleukin-1 family member 5 Interleukin-1 HY1 Interleukin-1 receptor antagonist homolog 1 Interleukin-1-like protein 1 Interleukin-36 Receptor Antagonist

Research Areas for IL-36Ra/IL-1F5

Find related products by research area and learn more about each of the different research areas below.

Biologically Active Proteins