Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for IL-36 beta/IL-1F8 Antibody [Unconjugated]
family of interleukin 1-eta
IL1F8 (Canonical product IL-1F8a)
interleukin 1 family, member 8 (eta)
interleukin 1, eta
Interleukin 36, Beta
interleukin-1 family member 8
Interleukin-1 homolog 2
Interleukin-1 Superfamily e
Mouse interleukin-36 beta [IL-36 beta ; also named IL-1F8, interleukin 1 family member 8, FIL-1 eta (eta) and IL-1H2] is a member of the IL-1 family of proteins (1‑3). IL-1 family members include IL‑1 beta, IL-1 alpha, IL-1ra, IL-18 and IL-1F5 through F10 (4). All family members show a 12 beta -stranded beta -trefoil configuration, and are believed to have arisen from a common ancestral gene that has undergone multiple duplications (4). Although two alternatively spliced transcript variants for human IL-1F8 have been described, to date, only one mouse IL-1F8 isoform is known (3). Mouse IL-1F8 is synthesized as a 183 amino acid (aa) protein that contains no signal sequence, no prosegment and no potential N-linked glycosylation site(s) (1, 2). It is likely that mouse IL-1F8, similarly to its human homologue, is actively secreted (1). Mouse IL-1F8 shares 61% and 74% aa identity with human IL-1F8 isoform 2 and rat IL-1F8, respectively. Within the IL-1 family, IL-1F8 shares 27% sequence with 33%, 32%, 35%, 39% and 28% aa sequence identity with IL-1 ra, IL-1 beta, IL-1F5, F6, F9 and F10, respectively. Cells reported to express IL-1F8 include resting and activated monocytes and B cells (1, 4). The receptor for IL-1F8 is reported to be a combination of IL-1 Rrp2 and IL-1 RAcP (5). Recombinant IL-1F8, along with IL-1F6 and IL-1F9, has been shown to activate the pathway involving NF-kappa B and MAPK in an IL-1Rrp2 dependent manner.
Smith, D.E. et al. (2000) J. Biol. Chem. 275:1169.
Kumar, S. et al. (2000) J. Biol. Chem. 275:10308.
Nicklin, M.J.H. et al. (2002) Genomics. 79:718.
Dunn, E. et al. (2001) Trends Immunol. 22:533.
Towne, J.E. et al. (2004) J. Biol. Chem. 279:13677.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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