IL-18/IL-1F4 Antibody [Alexa Fluor™ Plus 488]

• Reactivity: Ca
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 488

IL-18/IL-1F4 Antibody [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects canine IL‑18/IL‑1F4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant porcine IL-18 is observed, 20% cross-reactivity with recombinant rhesus macaque IL-18 is observed, 15% cross-reactivity with recombinant human IL-18 is observed, and 5% cross-reactivity with recombinant mouse IL-18 and recombinant rat IL-18 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-18/IL-1F4 Antibody [Alexa Fluor™ Plus 488]

• Iboctadekin
• IFN-gamma-inducing factor
• IGIF
• IGIFIL-1 gamma
• IL18
• IL-18
• IL-18MGC12320
• IL-1F4
• IL1F4iboctadekin
• IL-1g
• Interferon gamma-inducing factor
• interleukin 18 (interferon-gamma-inducing factor)
• Interleukin-1 gamma
• interleukin-18

Background

IL-18, also known as interferon-gamma-inducing factor (IGIF) and IL-18, is an 18 kDa protein belonging to the IL-1 superfamily. It is synthesized as a 24 kDa pro-IL-18 and is processed by caspase 1 to form the active protein. IL-18 is produced by multiple cell types including monocyte/macrophages, dendritic cells, osteoblasts and keratinocytes. Mature IL-18 synergizes with IL-12 to induce differentiation of naïve Th cells into Th1 cells. It also plays multiple roles in other immune cell types including macrophages, NK cells and B cells. Canine and human mature IL-18 share 73% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.