IL-18/IL-1F4 Antibody (125-2H) [Unconjugated] (D044-3)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IP, ELISA(Cap), Neut
Clone
125-2H
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

IL-18/IL-1F4 Antibody (125-2H) [Unconjugated] Summary

Immunogen
Human IL-18/IL-1F4
Specificity
This antibody reacts with human IL-18 on Immunoprecipitation.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL18
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunoprecipitation
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.5-2.0 ug/mL
  • Neutralization
  • ELISA Standard (Matched Pair)
Publications
Read Publications using
D044-3 in the following applications:

Packaging, Storage & Formulations

Storage
This antibody solution is stable for one year from the date of purchase when stored at -20°C.
Buffer
100 μg IgG in 100 μL volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Preservative
No Preservative

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-18/IL-1F4 Antibody (125-2H) [Unconjugated]

  • Iboctadekin
  • IFN-gamma-inducing factor
  • IGIF
  • IGIFIL-1 gamma
  • IL18
  • IL-18
  • IL-18MGC12320
  • IL-1F4
  • IL1F4iboctadekin
  • IL-1g
  • Interferon gamma-inducing factor
  • interleukin 18 (interferon-gamma-inducing factor)
  • Interleukin-1 gamma
  • interleukin-18

Background

Interleukin 18 (IL-18) is a 18 kDa cytokine which identified as a costimulatory factor for production of interferon-gamma (IFN-gamma ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-gamma is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-gamma activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. Pleiotropic effects of IL-18 has also been reported, such as, enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-gamma in T cells, enhancement of Fas ligand expression by Th1 cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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D044-3
Species: Hu
Applications: IP, ELISA(Cap), Neut

Publications for IL-18/IL-1F4 Antibody (D044-3)(16)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 9 applications: Antibody Array Development, ELISA Capture, ELISA Microarray Development, ELISA detection, Flow, Functional Assay, ICC, Luminex Development, Neut.


Filter By Application
Antibody Array Development
(1)
ELISA Capture
(2)
ELISA Microarray Development
(1)
ELISA detection
(1)
Flow
(1)
Functional Assay
(1)
ICC
(1)
Luminex Development
(1)
Neut
(7)
All Applications
Filter By Species
Human
(16)
All Species
Showing Publications 1 - 10 of 16. Show All 16 Publications.
Publications using D044-3 Applications Species
E Briend, GJ Ferguson, M Mori, G Damera, K Stephenson, NA Karp, S Sethi, CK Ward, MA Sleeman, JS Erjefält, DK Finch IL-18 associated with lung lymphoid aggregates drives IFN? production in severe COPD Respir. Res., 2017;18(1):159. 2017 [PMID: 28830544] (ELISA Capture,, Human) ELISA Capture Human
Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling Sci Rep, 2016;6(0):32320. 2016 [PMID: 27586092] (Flow,, Human) Flow Human
Bacillus Calmette-Gu�rin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses J Immunol, 2016;0(0):. 2016 [PMID: 27412415] (Neut,, Human) Neut Human
Martin R Goodier Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection J Immunol, 2016;197(1):313-25. 2016 [PMID: 27233958] (Neut,, Human) Neut Human
Spallanzani R, Torres N, Avila D, Ziblat A, Iraolagoitia X, Rossi L, Domaica C, Fuertes M, Rabinovich G, Zwirner N Regulatory Dendritic Cells Restrain NK Cell IFN-gamma Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors. J Immunol, 2015;195(5):2141-8. 2015 [PMID: 26232426] (ELISA Capture,, Human) ELISA Capture Human
Tsai C, Liong K, Gunalan M, Li N, Lim D, Fisher D, Macary P, Leo Y, Wong S, Puan K, Wong S Type I IFNs and IL-18 regulate the antiviral response of primary human gammadelta T cells against dendritic cells infected with Dengue virus. J Immunol, 2015;194(8):3890-900. 2015 [PMID: 25732728] (Neut,, Human) Neut Human
Hedl M, Zheng S, Abraham C The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways. J Immunol, 2014;192(12):5924-32. 2014 [PMID: 24842757] (Neut,, Human) Neut Human
Jitprasertwong P, Jaedicke K, Nile C, Preshaw P, Taylor J Leptin enhances the secretion of interleukin (IL)-18, but not IL-1beta, from human monocytes via activation of caspase-1. Cytokine, 2013;65(2):222-30. 2013 [PMID: 24275551] (ELISA detection,, Human) ELISA detection Human
Venkatesan B, Valente AJ, Reddy VS, Siwik DA, Chandrasekar B Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration. Am. J. Physiol. Heart Circ. Physiol., 2009;297(2):H874-86. 2009 [PMID: 19561311] (Neut,, Human) Neut Human
Hu H, Kwun J, Aizenstein BD, Knechtle SJ Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation, 2009;87(12):1814-20. 2009 [PMID: 19543058] (Antibody Array Development,, Human) Antibody Array Development Human
Show All 16 Publications.

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Bioinformatics

Gene Symbol IL18
Entrez