IL-17RB Antibody (RM0105-9J28)

Product Discontinued

IL-17RB Antibody (RM0105-9J28) Summary

• Immunogen: Mouse recombinant protein of the extracellular domain of IL-17B R
• Specificity: This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse recombinant protein of the extracellular domain of IL-17B R.
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Rat
• Gene: IL17RB
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000
• Application Notes: This antibody detects mouse IL-17B R in Western blotting, but not mouse IL-17 R.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from 0.2 um filtered PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for IL-17RB Antibody (RM0105-9J28)

• CRL4IL-17 receptor homolog 1
• cytokine receptor CRL4
• Cytokine receptor-like 4
• Evi27
• EVI27IL-17B receptor
• IL-17 RB
• IL-17 receptor B
• IL-17 RH1
• IL17BRinterleukin 17B receptor
• IL-17ER
• IL17RB
• IL-17RB
• IL17Rh1
• IL-17Rh1
• IL17RH1MGC5245
• interleukin 17 receptor B
• interleukin 17 receptor homolog 1
• interleukin-17 receptor B
• Interleukin-17B receptor

Background

Recently, a number of cytokines belonging to the interleukin IL17 family have been identified. These are termed as IL17B, IL17C and IL17E. IL17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL17B, C, and E like IL17 are able to induce proinflammatory responses. However, they do not bind to the IL17 receptor suggesting that additional IL17R related receptor might exist. Receptor for IL17B and IL17E have been independently isolated and have been designated as EV127 (in mouse) and IL17RH1 (in human), respectively. IL17E induces activation of NFkB pathway and like IL17 also induces production of IL8. IL17RH1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IL17RB