IL-12 R beta 2 Antibody (622509) [Alexa Fluor® 532]

• Applications: WB
• Clone: 622509
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

IL-12 R beta 2 Antibody (622509) [Alexa Fluor® 532] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human IL-12 Rβ2
  Lys24-Cys622
  Accession # Q99665
• Specificity: Detects human IL-12 R beta 2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human IL‑12 R beta 1 or recombinant mouse IL-12 R beta 1 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

IL-12 R beta 2 is a type I cytokine receptor family protein that associates with IL 12 R beta 1 to form a functional high affinity receptor complex for IL-12. The extracellular region of IL 12 R beta 2 contains five fibronectin type 3 domains. The cytoplasmic region is alternatively spliced, giving rise to two isoforms. IL-12 R beta 2 is up‑regulated in Th1 cells during inflammatory responses. The extracellular regions of human and mouse IL‑12 R beta 2 share 69% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.