Species: Mu
Applications: B/N
Host: Rat Monoclonal
Species: Hu
Applications: WB, B/N
Host: Goat Polyclonal
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Bioactivity
Description
IL12RB2 is encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
3595 |
| Alternate Names |
- IL-12 receptor beta 2
- IL-12 receptor subunit beta-2
- IL-12R subunit beta-2
- IL-12RB2
- IL-12R-beta-2
- interleukin 12 receptor, beta 2
- interleukin-12 receptor beta-2 chain
- interleukin-12 receptor subunit beta-2
|
Research Areas for IL-12 R beta 2
Find related products by research area and learn more about each of the different research areas below.
Cell Cycle and Replication
![Binding Activity IL-12 R beta 2 [Biotin]](http://images.novusbio.com/fullsize2/avi10930_recombinant-human-il-12-r-beta-2-fc-avi-tag-protein-cf-binding-activity-2392021111416.jpg)
![SDS-PAGE IL-12 R beta 2 [Biotin]](http://images.novusbio.com/fullsize2/avi10930_recombinant-human-il-12-r-beta-2-fc-avi-tag-protein-cf-sds-page-18112021174344.jpg)