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IL12RB2 is encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]
![Binding Activity IL-12 R beta 2 [Biotin]](http://images.novusbio.com/fullsize/avi10930_recombinant-human-il-12-r-beta-2-fc-avi-tag-protein-cf-binding-activity-2392021111416.jpg)
![SDS-Page IL-12 R beta 2 [Biotin]](http://images.novusbio.com/fullsize/avi10930_recombinant-human-il-12-r-beta-2-fc-avi-tag-protein-cf-sds-page-18112021174344.jpg)