IL-11R alpha Antibody (1020854) [Alexa Fluor™ Plus 555]

• Clone: 1020854
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

IL-11R alpha Antibody (1020854) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human IL-11 R alpha in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-11R alpha Antibody (1020854) [Alexa Fluor™ Plus 555]

• AI314697
• GP130
• IL-11 R alpha
• IL11R alpha
• IL11RA
• IL-11Ra
• Il11ra2
• NR1

Background

Interleukin-11 receptor alpha (IL-11 R alpha ) is a 49 kDa type I transmembrane member of the gp130 subfamily of the hematopoietic cytokine receptor family (1-3). Mature human IL-11 R alpha consists of a 347 amino acid (aa) extracellular domain (ECD) that contains a C2 type Ig-like domain, two fibronectin type III domains, two potential glycosylation sites, and a WSxWS motif, followed by a 21 aa transmembrane region and a 31 aa cytoplasmic domain (4). Within the ECD, human IL-11 R alpha shares 84%, 82%, 90%, and 86% aa sequence identity with mouse, rat, equine, and bovine IL-11 R alpha , respectively. Alternative splicing generates an additional isoform that lacks the cytoplasmic domain (4). Upon low affinity binding to IL-11, IL-11 R alpha associates with gp130 to form a high affinity receptor complex (1, 3). gp130 also functions as a subunit in the receptors for Cardiotrophin-1, CNTF, IL-6, IL-27, IL-31, LIF, and Oncostatin M (5). IL-11 R alpha is widely expressed in adults, embryos, and embryonic stem cells (4, 6, 7). Deletion of IL-11 R alpha in female mice causes faulty decidualization, lack of decidual NK cells, and infertility (8-10). IL-11 is anti-apoptotic for oligodendrocytes, and lack of IL-11 R alpha increases the severity of experimental autoimmune encephalitis (11, 12). IL-11 R alpha is also anti-apoptotic for colonic epithelia, and increased IL-11 signaling may be a factor in inflammation-associated gastrointestinal cancer development (3, 13). IL-11 R alpha enhances osteoclast differentiation and bone remodeling but inhibits adipocyte differentiation (1, 2). Recombinant soluble IL-11 R alpha confers IL-11 responsiveness to cells expressing gp130, while in cells expressing transmembrane IL-11 R alpha and gp130, soluble IL-11 R alpha acts as an IL-11 antagonist (14-16).

1. Sims, N.A. and N.C. Walsh (2010) BMB Reports 43:513.
2. White, U.A. and J.M. Stephens (2011) Curr. Pharm. Des. 17:340.
3. Kiessling, S. et al. (2004) J. Biol. Chem. 279:10304.
4. Cherel, M. et al. (1995) Blood 86:2534.
5. Garbers, C. et al. (2012) Cytokine Growth Factor Rev. 23:85.
6. Hilton, D.J. et al. (1994) EMBO J. 13:4765.
7. Davidson, A.J. et al. (1997) Stem Cells 15:119.
8. Paiva, P. et al. (2009) Cytokine Growth Factor Rev. 20:319.
9. Robb, L. et al. (1998) Nat. Med. 4:303.
10. Ain, R. et al. (2004) Dev. Dyn. 231:700.
11. Gurfein, B.T. et al. (2009) J. Immunol. 183:4229.
12. Zhang, J. et al. (2011) J. Immunol. 187:1129.
13. Putoczki, T. and M. Ernst (2010) J. Leukoc. Biol. 88:1109.
14. Curtis, D.J. et al. (1997) Blood 90:4403.
15. Baumann, H. et al. (1996) J. Immunol. 157:284.
16. Karow, J. et al. (1996) Biochem. J. 318:489.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.