IKK gamma Antibody (46B844)

Images

 
Western Blot: IKK gamma Antibody (46B844) [NB100-56532] - Analysis using NEMO (IKKgamma) antibody. Lysate from human Jurkat cells probed with NEMO antibody at 2 ug/ml. The goat anti-mouse IgG1 HRP secondary and PicoTect ...read more
Flow Cytometry: IKK gamma Antibody (46B844) [NB100-56532] - Human Jurkat cells were probed using 0.1 ug of NEMO antibody (red) and 0.1 ug of isotype control (green), with shaded histogram representing cells alone and an ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow
Clone
46B844
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.5 mg/ml

IKK gamma Antibody (46B844) Summary

Immunogen
Full-length human NEMO (IKKgamma) protein
Specificity
A 48 kDa band is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IKBKG
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml
  • Flow Cytometry 1:10-1:1000
Antagonist
Publications
Read Publications using NB100-56532.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for IKK gamma Antibody (46B844)

  • FIP-3IP2
  • FIP3NF-kappa-B essential modifier
  • FIP3P
  • I-kappa-B kinase subunit gamma
  • IkB kinase gamma subunit
  • IkB kinase subunit gamma
  • IkB kinase-associated protein 1
  • IKBKG
  • IKK gamma
  • IKKAP1
  • IKKG
  • IKK-gammaIPD2
  • incontinentia pigmenti
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  • Inhibitor of nuclear factor kappa-B kinase subunit gamma
  • IP
  • IP1
  • NEMO
  • NEMOAMCBX1
  • NFkappaB essential modulator
  • NF-kappa-B essential modulator

Background

NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. IKK3/g preferentially interacts with IKK2/b and is required for activation of IKK complex. IKK3/g is also known as NEMO (NF-kB Essential MOdulator). Recent data suggest that the human T-cell leukemia virus type I Tax oncoprotein that activates NF-kB binds neither to IKKa nor IKKb, but complexes directly with IKKg. This suggests that IKKg may be a key molecule acting as an adapter for onco-protein specific signaling to IKKa and IKKb.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IKK gamma Antibody (NB100-56532)(5)

We have publications tested in 1 application: WB.


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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for IKK gamma Antibody (NB100-56532) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-56532AF405
Alexa Fluor 488 Labeled NB100-56532AF488
Alexa Fluor 647 Labeled NB100-56532AF647
Alexa Fluor 700 Labeled NB100-56532AF700
Allophycocyanin Labeled NB100-56532APC
Biotin Labeled NB100-56532B
DyLight 350 Labeled NB100-56532UV
DyLight 405 Labeled NB100-56532V
DyLight 488 Labeled NB100-56532G
DyLight 550 Labeled NB100-56532R
DyLight 650 Labeled NB100-56532C
DyLight 680 Labeled NB100-56532FR
DyLight 755 Labeled NB100-56532IR
HRP Labeled NB100-56532H
PE Labeled NB100-56532PE
PerCP Labeled NB100-56532PCP

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Blogs on IKK gamma.

Regulating Immune Response Pathways with IKK beta
IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f...  Read full blog post.

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Bioinformatics

Gene Symbol IKBKG
Entrez
Uniprot