WB, Simple WesternHost:
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal
Hu, Mu, RtApplications:
Func-Inh, In vitro, In vivo, B/N
Applications: WB, ELISA, Func, PA, AP, KA
Applications: WB, ELISA, PA, AP
Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males (The International Incontinentia Pigmenti Consortium, 2000 [PubMed 10839543]). In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito (MIM 300337).[supplied by OMIM]
|Product By Gene ID
- NFkappaB essential modulator
- NF-kappa-B essential modulator
- IkB kinase gamma subunit
- Inhibitor of nuclear factor kappa-B kinase subunit gamma
- IkB kinase-associated protein 1
- IkB kinase subunit gamma
- incontinentia pigmenti
- FIP3NF-kappa-B essential modifier
- I-kappa-B kinase subunit gamma
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Bioinformatics Tool for IKK gamma
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|Regulating Immune Response Pathways with IKK beta
IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f... Read more.