IGFBP-6 Products

Antibodies
IGFBP-6 Antibody (110211)
IGFBP-6 Antibody (110211)
MAB8761
Species: Hu
Applications: WB, ELISA(Cap)
Host: Mouse Monoclonal
IGFBP-6 Antibody
IGFBP-6 Antibody
AF876
Species: Hu
Applications: WB, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
IGFBP-6 Antibody [Unconjugate ...
IGFBP-6 Antibody [Unconjugated]
AF776
Species: Mu
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
IGFBP-6 ELISA Kit [Biotin]
IGFBP-6 ELISA Kit [Biotin]
KA1790
Species: Mu
IGFBP-6 ELISA Kit [Biotin]
IGFBP-6 ELISA Kit [Biotin]
KA1728
Species: Hu
Lysates
IGFBP-6 Overexpression Lysate ...
IGFBP-6 Overexpression Lysate (Den...
H00003489-T01
Species: Hu
Applications: WB
IGFBP-6 Overexpression Lysate ...
IGFBP-6 Overexpression Lysate (Nat...
NBL1-11876
Applications: WB
Proteins
IGFBP-6 Recombinant Protein A ...
IGFBP-6 Recombinant Protein Antigen
NBP1-86495PEP
Species: Hu
Applications: AC
IGFBP-6 Recombinant Protein
IGFBP-6 Recombinant Protein
NBP2-52383
Species: Mu
Applications: PAGE
IGFBP-6 Recombinant Protein
IGFBP-6 Recombinant Protein
NBP2-23141
Species: Hu
Applications: PAGE
RNAi
IGFBP-6 RNAi
IGFBP-6 RNAi
H00003489-R01
Species: Hu

Description

Data show that an increase in JNK activation in the presence of NFkappaB inhibition significantly increased the expression of IGFBP6. These studies provide evidence that over expression of IGFBP-6 suppresses human and murine osteoblast differentiation, that IGFBP-6 and LMP-1 physically interact, and supports the conclusion that this interaction may be functionally relevant. IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. Observational study of gene-disease association. (HuGE Navigator) IGFBP-6 is translocated to the nucleus with functional consequences, and different members of the IGFBP family have specific nuclear import mechanisms. Toxic effect of TCDD on osteogenesis through altering IGFBP6 gene expression in osteoblasts is reported. p38 MAPK is involved in IGFBP-6-induced IGF-independent rhabdomyosarcoma cell migration. determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation. Inhibition of human osteoblast marker gene expression by retinoids is mediated in part by insulin-like growth factor binding protein-6. A close correlation exists between residues of the carboxyl-terminal domain of IGFBP6 undergoing conformational change in 15N NMR spectroscopy studies with those that disappeared or broadened upon insulin-like growth factor (IGF-II) binding. C-domain of IGFBP-6 consists of a thyroglobulin type 1 fold comprising an alpha-helix followed by a loop, a three-stranded antiparallel beta-sheet incorporating a second loop, and a disulfide-bonded flexible third loop. The expression of certain IGFBP is significantly altered in renal cell carcinoma. CCI-779 acts additively with IGFBP-6 to reduce rhabdomyosarcoma growth both in vitro and in vivo. may function as an antiproliferative molecule suppressing mitogenic effects of insulin-like growth factors on Malassez cells. The IGFBP-6 protein is synthesized as propeptides with a hydrophobic leader sequence, removal of which yields a mature protein composed of 3 recognizable domains of similar size. transgenic human IGFBP-6 mice may be considered a new tool for studies of the involvement of the brain IGF system in metabolism control and obesity.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 3489
Alternate Names
  • IGFBP-6
  • insulin-like growth factor-binding protein 6
  • IBP6
  • IGF binding protein 6
  • IBP-6
  • IGF-binding protein 6
  • insulin-like growth factor binding protein 6

Research Areas for IGFBP-6

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication

PTMs for IGFBP-6

Learn more about PTMs related to IGFBP-6.

Methylation
Demethylation
Phosphorylation

Bioinformatics Tool for IGFBP-6

Discover related pathways, diseases and genes to IGFBP-6. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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