IGF-I R/IGF1R Antibody (IGF1R/4667) - Azide and BSA Free

Protein Array: IGF-I R/IGF1R Antibody (IGF1R/4667) - Azide and BSA Free [NBP3-14094] - Analysis of Protein Array containing more than 19,000 full-length human proteins using IGF-I R/IGF1R Antibody (IGF1R/4667).

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with IGF-I R/IGF1R Antibody (IGF1R/4667) - Azide and BSA Free.

Formalin-fixed, paraffin-embedded human colon carcinoma stained with IGF-I R/IGF1R Antibody (IGF1R/4667) - Azide and BSA Free.

Formalin-fixed, paraffin-embedded human breast carcinoma stained with IGF-I R/IGF1R Antibody (IGF1R/4667) - Azide and BSA Free.

• Reactivity: Hu
• Applications: Flow, ICC/IF, MA
• Clone: IGF1R/4667
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 1 mg/ml

IGF-I R/IGF1R Antibody (IGF1R/4667) - Azide and BSA Free Summary

• Description: 1.0 mg/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP3-13948).
  
  Antibody without azide - store at -20 to -80C. Antibody with azide - store at 2 to 8C. Non-hazardous.
  
  Theoretical molecular weight: 130kDa (IGF-1R); 97kDa (IGF-1R); 200kDa (pro-IGF-1R)
• Immunogen: Recombinant fragment (around aa550-750) of human IGF-I R/IGF1R protein (exact sequence is proprietary) (Uniprot: P08069)
• Localization: Cell membrane
• Isotype: IgG2c Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: IGF1R
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1-2 ug/million cells
  • Immunocytochemistry/ Immunofluorescence 1-4 ug/ml
  • Protein Array
• Application Notes: In-vitro Neutralization of Biological Activity of IGF-1: Order this antibody without Azide

Packaging, Storage & Formulations

• Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
• Buffer: 10mM PBS
• Preservative: No Preservative
• Concentration: 1 mg/ml
• Purity: Protein A or G purified

Alternate Names for IGF-I R/IGF1R Antibody (IGF1R/4667) - Azide and BSA Free

• CD221 antigen
• CD221
• EC 2.7.10
• EC 2.7.10.1
• IGF1R
• IGF-1R
• IGF-I R
• IGF-I receptor
• IGFIR
• IGF-IR
• IGFR
• insulin-like growth factor 1 receptor
• Insulin-like growth factor I receptor
• JTK13
• MGC142170
• MGC142172
• MGC18216
• soluble IGF1R variant 1
• soluble IGF1R variant 2

Background

The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IGF1R