IGF-I R/IGF1R Products

Description

The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival

Bioinformatics

Entrez	101883 Mouse 16001 Mouse 25718 Rat 3480 Human
Uniprot	NM_000875 Human NP_000866 Human NP_000866.1 Human P08069 Human
Product By Gene ID	3480
Alternate Names	CD221 antigen CD221 EC 2.7.10 EC 2.7.10.1 IGF-I receptor IGFIR IGFR insulin-like growth factor 1 receptor Insulin-like growth factor I receptor JTK13 MGC142170 MGC142172 MGC18216 soluble IGF1R variant 1 soluble IGF1R variant 2

Research Areas for IGF-I R/IGF1R

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Lipid and Metabolism
Neuroscience
Nutrient Sensing in the Brain
Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases