IgE Antibody (TES-C21) - Chimeric - Azide and BSA Free

• Reactivity: Hu
• Applications: ELISA, B/N
• Clone: TES-C21
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 1 mg/ml

IgE Antibody (TES-C21) - Chimeric - Azide and BSA Free Summary

• Description: Novus Biologicals Rabbit IgE Antibody (TES-C21) - Chimeric - Azide and BSA Free (NBP3-09009) is a recombinant monoclonal antibody validated for use in ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Polyclonal human IgE.
• Isotype: IgG Kappa
• Clonality: Monoclonal
• Host: Rabbit
• Gene: IGHE
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Block/Neutralize
  • ELISA
• Application Notes: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
  
  The antibody binds specifically to IgE, an immunoglobulin isotype secreted by upon stimulation of B cells by interleukins Il-4 and IL-13. IgE provides immunity to parasites such as helminths and Plasmodium falciparum. The immunoglobulin also plays a central role in the development of Type I hypersensitivity reactions and allergic diseases such as asthma, sinusitis and food allergies. These allergic responses are triggered by the binding of IgE to the high affinity receptor Fc epsilon RI, expressed on the surface of basophils and mast cells. Binding of IgE causes cross-linking of the receptor, inducing degranulation and release of inflammatory mediators, particularly of histamine. The monoclonal antibody TES-C21 binds to secreted IgE and to IgE expressed on the surface of IgE-producing B cells, thereby inhibiting IgE binding to Fc epsilon RI and the release of histamine from mast cells. The monoclonal antibody can have diagnostic applications, such as for identifying and quantifying IgE-expressing B cells and IgE levels in serum samples, and therapeutic applications in the treatment of allergies. Furthermore, the antibody can conjugated to cytotoxic drugs and deliver them specifically to IgE-producing B cells.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Proclin 300
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for IgE Antibody (TES-C21) - Chimeric - Azide and BSA Free

• IgE
• immunoglobulin heavy constant epsilon

Background

IgE is typically the least abundant isotype - blood serum IgE levels in a normal ("non-atopic") individual are ~150 ng/ml, compared to 10 mg/ml for the IgGs - it is capable of triggering the most powerful immune reactions. Most of our knowledge of IgE has come from research into the mechanism of a form of allergy known as type 1 hypersensitivity. There is much speculation into what physiological benefits IgE contributes, and so far, circumstantial evidence in animal models and statistical population trends have hinted that IgE may be beneficial in fighting gut parasites such as Schistosoma mansoni, but this has not been conclusively proven in humans. IgE may play an important role in the immune system's recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. IgE may be an important target in treatments for allergy and asthma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IGHE