Mouse anti-Canine IgE Secondary Antibody (E6-71A1) [Biotin]

Product Discontinued

Mouse anti-Canine IgE Secondary Antibody (E6-71A1) [Biotin] Summary

• Immunogen: Affinity purified IgE preparation from heavily parasitized and allergic dog serum.
• Specificity: Mouse anti Dog IgE antibody, clone E6-71A1, recognizes canine IgE.This antibody does not cross-react with dog IgM, IgA, IgG1 or IgG2.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: IGHE
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Mouse anti-Canine IgE Secondary Antibody (E6-71A1) [Biotin]

• IgE
• immunoglobulin heavy constant epsilon

Background

IgE is typically the least abundant isotype - blood serum IgE levels in a normal ("non-atopic") individual are ~150 ng/ml, compared to 10 mg/ml for the IgGs - it is capable of triggering the most powerful immune reactions. Most of our knowledge of IgE has come from research into the mechanism of a form of allergy known as type 1 hypersensitivity. There is much speculation into what physiological benefits IgE contributes, and so far, circumstantial evidence in animal models and statistical population trends have hinted that IgE may be beneficial in fighting gut parasites such as Schistosoma mansoni, but this has not been conclusively proven in humans. IgE may play an important role in the immune system's recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. IgE may be an important target in treatments for allergy and asthma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Secondary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IGHE