Human VEGFR1/Flt-1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human VEGFR1/Flt-1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: FLT1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human VEGFR1/Flt-1 DuoSet ELISA, 15 Plate

• EC 2.7.10
• EC 2.7.10.1
• FLT
• FLT1
• Flt-1
• Fms-like tyrosine kinase 1
• fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor)
• FRT
• Tyrosine-protein kinase FRT
• Tyrosine-protein kinase receptor FLT
• vascular endothelial growth factor receptor 1
• Vascular permeability factor receptor
• VEGF R1
• VEGFR1
• VEGFR-1

Background

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.

Publications for VEGFR1/Flt-1 (DY321B)(28)

Publications using DY321B

• López-Guzmán, C;García, AM;Marín, P;Vásquez, AM; Assessment of the Integrity and Function of Human Term Placental Explants in Short-Term Culture Methods and protocols 2024-02-15 [PMID: 38392690] (Human)
• Lekva, T;Sundaram, AYF;Roland, MCP;Åsheim, J;Michelsen, AE;Norwitz, ER;Aukrust, P;Gilfillan, GD;Ueland, T; Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia-an exploratory study BMC medicine 2023-11-23 [PMID: 37996819] (Human)
• E Kadife, N Hannan, A Harper, N Binder, S Beard, FC Brownfoot Hydroxychloroquine reduces soluble Flt-1 secretion from human cytotrophoblast, but does not mitigate markers of endothelial dysfunction in vitro PLoS ONE, 2022-11-23;17(11):e0271560. 2022-11-23 [PMID: 36417467] (Human)
• BR Fato, N de Alwis, S Beard, NK Binder, N Pritchard, S Tong, TJ Kaitu'u-Li, NJ Hannan Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries-A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development International Journal of Molecular Sciences, 2022-09-16;23(18):. 2022-09-16 [PMID: 36142764] (Human)
• S Macdonald, E Bosio, NI Shapiro, L Balmer, S Burrows, M Hibbs, T Jowitt, L Smart, G Arendts, D Fatovich No association between intravenous fluid volume and endothelial glycocalyx shedding in patients undergoing resuscitation for sepsis in the emergency department Scientific Reports, 2022-05-24;12(1):8733. 2022-05-24 [PMID: 35610344] (Human)
• SC Lean, RL Jones, SA Roberts, AEP Heazell A prospective cohort study providing insights for markers of adverse pregnancy outcome in older mothers BMC pregnancy and childbirth, 2021-10-20;21(1):706. 2021-10-20 [PMID: 34670515] (Human)
• N de Alwis, S Beard, NK Binder, N Pritchard, TJ Kaitu'u-Li, SP Walker, O Stock, KM Groom, S Petersen, A Henry, JM Said, S Seeho, SC Kane, S Tong, NJ Hannan NR4A2 expression is not altered in placentas from cases of growth restriction or preeclampsia, but is reduced in hypoxic cytotrophoblast Scientific Reports, 2021-10-19;11(1):20670. 2021-10-19 [PMID: 34667209] (Human)
• Y Sun, L Tan, RI Neuman, M Broekhuize, S Schoenmake, X Lu, AHJ Danser Megalin, Proton Pump Inhibitors and the Renin-Angiotensin System in Healthy and Pre-Eclamptic Placentas International Journal of Molecular Sciences, 2021-07-10;22(14):. 2021-07-10 [PMID: 34299027] (Human)
• S Hong, JE Lee, YM Kim, Y Park, JW Choi, KH Park Identifying potential biomarkers related to pre-term delivery by proteomic analysis of amniotic fluid Sci Rep, 2020-11-12;10(1):19648. 2020-11-12 [PMID: 33184413] (Human)
• LM Gierman, GB Silva, Z Pervaiz, JJ Rakner, SB Mundal, AJ Thaning, I Nervik, M Elschot, S Mathew, LCV Thomsen, L Bjørge, AC Iversen TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies J. Leukoc. Biol., 2020-06-23;0(0):. 2020-06-23 [PMID: 32573856] (Human)
• AC Eddy, H Chapman, DT Brown, EM George Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells Biosci. Rep., 2020-02-28;40(2):. 2020-02-28 [PMID: 32039444] (Human)
• A Djeha, S Girard, H Trottier, F Kakkar, H Soudeyns, M Boucher, N Lapointe, I Boucoiran No association between early antiretroviral therapy during pregnancy and plasma levels of angiogenic factors: a cohort study BMC Pregnancy Childbirth, 2019-12-09;19(1):482. 2019-12-09 [PMID: 31815612] (Human)
• FC Brownfoot, NJ Hannan, P Cannon, V Nguyen, R Hastie, LJ Parry, S Senadheera, L Tuohey, S Tong, TJ Kaitu'u-Li Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction EBioMedicine, 2019-02-26;0(0):. 2019-02-26 [PMID: 30824385] (Human)
• NJ Hannan, NK Binder, S Beard, TV Nguyen, TJ Kaitu'u-Li, S Tong Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia PLoS ONE, 2018-04-11;13(4):e0187082. 2018-04-11 [PMID: 29641523] (Human)
• P Mésange, A Bouygues, N Ferrand, M Sabbah, AE Escargueil, A Savina, B Chibaudel, C Tournigand, T Andre, A de Gramont, AK Larsen Combinations of Bevacizumab and Erlotinib show activity in colorectal cancer independent of RAS status Clin. Cancer Res., 2018-02-28;0(0):. 2018-02-28 [PMID: 29490990] (Human)
• SC Lean, AEP Heazell, MR Dilworth, TA Mills, RL Jones Placental Dysfunction Underlies Increased Risk of Fetal Growth Restriction and Stillbirth in Advanced Maternal Age Women Sci Rep, 2017-08-29;7(1):9677. 2017-08-29 [PMID: 28852057] (Human)
• B Kramer, JD Schultz, C Hock, A Sauter, BA Stuck, K Hörmann, R Birk, C Aderhold Effect of selective small molecule inhibitors on MMP-9 and VEGFR-1 expression in p16-positive and -negative squamous cell carcinoma Oncol Lett, 2017-03-13;13(5):3269-3276. 2017-03-13 [PMID: 28521433] (Human)
• Angiogenic proteins, placental weight and perinatal outcomes among pregnant women in Tanzania PLoS ONE, 2016-12-09;11(12):e0167716. 2016-12-09 [PMID: 27936130] (Human)
• Kumar N, Moideen K, Sivakumar S, Menon P, Viswanathan V, Kornfeld H, Babu S Tuberculosis-diabetes co-morbidity is characterized by heightened systemic levels of circulating angiogenic factors. J Infect, 2016-10-04;74(1):10-21. 2016-10-04 [PMID: 27717783] (Human)
• Kumar N, Banurekha V, Nair D, Babu S Circulating Angiogenic Factors as Biomarkers of Disease Severity and Bacterial Burden in Pulmonary Tuberculosis. PLoS ONE, 2016-01-04;11(1):e0146318. 2016-01-04 [PMID: 26727122] (Human)
• McDonald C, Darling A, Conroy A, Tran V, Cabrera A, Liles W, Wang M, Aboud S, Urassa W, Fawzi W, Kain K Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women. PLoS ONE, 2015-08-06;10(8):e0134619. 2015-08-06 [PMID: 26247200] (Human)
• Conroy A, Gelvez M, Hawkes M, Rajwans N, Liles W, Villar-Centeno L, Kain K Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study. BMC Infect Dis, 2014-01-20;14(0):35. 2014-01-20 [PMID: 24444080] (Human)
• Munaut C, Lorquet S, Pequeux C, Coulon C, Le Goarant J, Chantraine F, Noel A, Goffin F, Tsatsaris V, Subtil D, Foidart JM Differential expression of Vegfr-2 and its soluble form in preeclampsia. PLoS ONE, 2012-03-12;7(3):e33475. 2012-03-12 [PMID: 22428059] (Human)
• Kaitu'u-Lino TJ, Whitehead CL, Ngian GL, Permezel M, Tong S Serum concentrations of soluble Flt-1 are decreased among women with a viable fetus and no symptoms of miscarriage destined for pregnancy loss. PLoS ONE, 2012-02-28;7(2):e32509. 2012-02-28 [PMID: 22389705] (Human)
• Conroy AL, Liles WC, Molyneux ME Performance characteristics of combinations of host biomarkers to identify women with occult placental malaria: a case-control study from Malawi. PLoS ONE, 2011-12-12;6(12):e28540. 2011-12-12 [PMID: 22174834] (Human)
• Erdman LK, Dhabangi A, Musoke C, Conroy AL, Hawkes M, Higgins S, Rajwans N, Wolofsky KT, Streiner DL, Liles WC, Cserti-Gazdewich CM, Kain KC Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study. PLoS ONE, 2011-02-25;6(2):e17440. 2011-02-25 [PMID: 21364762] (Human)
• Lash GE, Naruse K, Innes BA, Robson SC, Searle RF, Bulmer JN Secretion of angiogenic growth factors by villous cytotrophoblast and extravillous trophoblast in early human pregnancy. Placenta, 2010-03-24;31(6):545-8. 2010-03-24 [PMID: 20338637] (Human)
• Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, Azuma M, Kinoshita K, Batmunkh R, Rentsenhand B, Makino H, Ranjan P, Minakuchi K, Sone S Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property. J. Immunol., 2009-12-15;183(12):8176-85. 2009-12-15 [PMID: 20007583] (Human)

Bioinformatics

• Gene Symbol: FLT1