Human Syndecan-1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Syndecan-1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: SDC1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Syndecan-1 DuoSet ELISA, 15 Plate

• CD138 antigen
• CD138
• SDC
• SDC1
• SYND1heparan sulfate proteoglycan fibroblast growth factor receptor
• syndecan 1
• syndecan proteoglycan 1
• syndecan
• Syndecan1
• Syndecan-1

Background

Syndecans are type 1 transmembrane proteoglycans that constitute the major physiological form of heparan sulfate (HS) on the cell surface. The four vertebrate syndecans, Syndecan-1 through -4, have similar short cytoplasmic domains and extracellular portions that diverge, except for HS attachment sites. Structurally diverse side chains add considerably to the size of the core proteins and serve as binding sites for growth factors, cytokines, and extracellular matrix proteins. Syndecans are present as homodimers or multimers, and are often expressed in developmental and cell type-specific patterns. They have many biological roles including regulating cell growth, differentiation, and adhesion.

Publications for Syndecan-1/CD138 (DY2780)(16)

Publications using DY2780

• de Oliveira Couto, H;Ovídio, PP;Jordão, AA;Miranda, CH; Endothelial glycocalyx shedding and oxidative stress in neuronal damage after return of spontaneous circulation in cardiac arrest Scientific reports 2025-11-25 [PMID: 41291001] (Human)
• Balistreri, CR;Magro, D;Scola, L;Aridon, P;Ragonese, P;Dos Santos Mendes, FA;Schirò, G;D'Amelio, M; Shed Syndecans (1-3), ELA-32, BDNF, NLR, and hs-CRP in Parkinson's Disease: Appropriate Diagnostic and Prognostic Biomarkers When Combined in a Unique Panel International journal of molecular sciences 2025-05-08 [PMID: 40429647] (Human)
• de Sousa, FTG;Warnes, CM;Manuli, ER;Ng, A;Zanella, LGFABD;Ho, YL;Bhat, S;Romano, CM;Beatty, PR;Biering, SB;Kallas, EG;Sabino, EC;Harris, E; Yellow fever disease severity and endothelial dysfunction are associated with elevated serum levels of viral NS1 protein and syndecan-1 medRxiv : the preprint server for health sciences 2023-06-30 [PMID: 37425955] (Human)
• S Asif, R Frithiof, A Larsson, S Franzén, SB Anderberg, B Kristensen, M Hultström, M Lipcsey Immuno-Modulatory Effects of Dexamethasone in Severe COVID-19-A Swedish Cohort Study Biomedicines, 2023-01-09;11(1):. 2023-01-09 [PMID: 36672672] (Human)
• S Macdonald, E Bosio, NI Shapiro, L Balmer, S Burrows, M Hibbs, T Jowitt, L Smart, G Arendts, D Fatovich No association between intravenous fluid volume and endothelial glycocalyx shedding in patients undergoing resuscitation for sepsis in the emergency department Scientific Reports, 2022-05-24;12(1):8733. 2022-05-24 [PMID: 35610344] (Human)
• LE Cabrera, C Schmotz, MA Saleem, S Lehtonen, O Vapalahti, A Vaheri, S Mäkelä, J Mustonen, T Strandin Increased Heparanase Levels in Urine during Acute Puumala Orthohantavirus Infection Are Associated with Disease Severity Viruses, 2022-02-22;14(3):. 2022-02-22 [PMID: 35336857] (Human)
• A Topf, M Mirna, N Bacher, V Paar, C Edlinger, LJ Motloch, S Gharibeh, M Bannehr, UC Hoppe, M Lichtenaue The Value of Fetuin-A as a Predictor to Identify Takotsubo Patients at Risk of Cardiovascular Events Journal of cardiovascular development and disease, 2021-10-05;8(10):. 2021-10-05 [PMID: 34677196] (Human)
• D Garcha, SP Walker, TM MacDonald, J Hyett, J Jellins, J Myers, SE Illanes, JK Nien, M Schepeler, E Keenan, CA Whigham, P Cannon, E Murray, TV Nguyen, M Kandel, J Masci, C Murphy, T Cruickshan, N Pritchard, NJ Hannan, F Brownfoot, A Roddy Mitc, A Middleton, G Pell, GP Wong, S Tong, TJ Kaitu'u-Li Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria Scientific Reports, 2021-08-16;11(1):16595. 2021-08-16 [PMID: 34400721] (Human)
• Z Uz, C Ince, L Shen, B Ergin, TM van Gulik Real-time observation of microcirculatory leukocytes in patients undergoing major liver resection Scientific Reports, 2021-02-25;11(1):4563. 2021-02-25 [PMID: 33633168] (Human)
• CS Oh, JM Choi, EH Park, L Piao, HJ Park, KY Rhee, SH Kim Impact of Anesthetic Agents on Endothelial Glycocalyx Injury during Total Knee Arthroplasty: Desflurane- vs. Propofol-Based Anesthesia-A Prospective Randomized Controlled Trial BioMed Research International, 2021-01-23;2021(0):8880267. 2021-01-23 [PMID: 33564684] (Human)
• AD Eustace, EF McNaughton, S King, O Kehoe, A Kungl, D Mattey, AH Nobbs, N Williams, J Middleton Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis Arthritis Res. Ther., 2019-07-12;21(1):172. 2019-07-12 [PMID: 31300004] (Human)
• L Smart, SPJ Macdonald, E Bosio, D Fatovich, C Neil, G Arendts Bolus therapy with 3% hypertonic saline or 0.9% saline in emergency department patients with suspected sepsis: A pilot randomised controlled trial J Crit Care, 2019-03-28;52(0):33-39. 2019-03-28 [PMID: 30954691] (Human)
• Graham S, Chen J, Chung D, Barker K, Conroy A, Hawkes M, Namasopo S, Kain K, Lopez J, Liles W Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial. Malar J, 2016-02-02;15(1):56. 2016-02-02 [PMID: 26830467] (Human)
• Zingoni A, Cecere F, Vulpis E, Fionda C, Molfetta R, Soriani A, Petrucci M, Ricciardi M, Fuerst D, Amendola M, Mytilineos J, Cerboni C, Paolini R, Cippitelli M, Santoni A Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells. J Immunol, 2015-06-12;195(2):736-48. 2015-06-12 [PMID: 26071561] (Human)
• Yini S, Heng Z, Xin A, Xiaochun M Effect of unfractionated heparin on endothelial glycocalyx in a septic shock model. Acta Anaesthesiol Scand, 2014-10-14;59(2):160-9. 2014-10-14 [PMID: 25312742] (Canine)
• Bam R, Venkateshaiah S, Khan S, Ling W, Randal S, Li X, Zhang Q, van Rhee F, Barlogie B, Epstein J, Yaccoby S Role of Bruton's tyrosine kinase (BTK) in growth and metastasis of INA6 myeloma cells. Blood Cancer J, 2014-08-01;4(0):e234. 2014-08-01 [PMID: 25083818] (Mouse)

FAQs for Syndecan-1/CD138 (DY2780). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: SDC1