Human RBP4 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human RBP4 Quantikine ELISA Kit Summary

Background
The Quantikine Human RBP4 immunoassay is a 2.5 hour solid phase ELISA designed to measure human RBP4 in cell culture supernates, serum, plasma, urine, and saliva. It contains NS0-expressed recombinant human RBP4 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human RBP4 showed linear curves that were parallel to the standard curves obtained ...using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human RBP4.
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Specificity
Natural and recombinant human RBP4
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
RBP4

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DRB400.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human RBP4 Quantikine ELISA Kit

  • interstitial
  • Plasma retinol-binding protein
  • RBP4
  • retinol binding protein 4, plasma
  • RetinolBinding Protein 4
  • retinol-binding protein 4, plasma

Background

Retinol-binding protein 4 (RBP4) is a Lipocalin superfamily molecule that transports vitamin A (retinol) and retinaldehyde in the serum. Retinaldehyde is the critical chromophore in the rhodopsin photoreceptor, while both it and retinoic acid regulate a multitude of cellular differentiation and proliferation effects through the intracellular receptors RAR and RXR. RBP4 is secreted primarily by hepatocytes and adipocytes into the blood where the RBP4-retinol complex interacts with transthyretin (TTR). Formation of the complex with TTR increases the serum half-life of RBP4 by preventing RBP4 filtration through the kidney. The C-terminally processed forms of RBP4, which do not bind TTR, are normally excreted into the urine but accumulate in the serum during renal failure. RBP4 promotes hyperglycemia, and its upregulation in visceral and liver adipocytes leads to elevated serum levels.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for RBP4/Retinol-Binding Protein 4 (DRB400)(15)

We have publications tested in 2 confirmed species: Human, Mouse.


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Human
(13)
Mouse
(2)
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Showing Publications 1 - 10 of 15. Show All 15 Publications.
Publications using DRB400 Applications Species
H Wessel, A Saeed, J Heegsma, MA Connelly, KN Faber, RPF Dullaart Plasma Levels of Retinol Binding Protein 4 Relate to Large VLDL and Small LDL Particles in Subjects with and without Type 2 Diabetes J Clin Med, 2019;8(11):. 2019 [PMID: 31717719] (Human) Human
D Kostic, GPNS Beozzo, SB do Couto, AHT Kato, L Lima, P Palmeira, VLJ Krebs, V Bunduki, RPV Francisco, M Zugaib, FT Dénes, WB de Carvalh, VHK Koch The role of renal biomarkers to predict the need of surgery in congenital urinary tract obstruction in infants J Pediatr Urol, 2019;0(0):. 2019 [PMID: 30979613] (Human) Human
JY Li, XX Chen, XH Lu, CB Zhang, QP Shi, L Feng Elevated RBP4 plasma levels were associated with diabetic retinopathy in type 2 diabetes Biosci. Rep., 2018;0(0):. 2018 [PMID: 30135138] (Human) Human
YY Zhu, JL Zhang, L Liu, Y Han, X Ge, S Zhao Evaluation of serum retinol-binding protein-4 levels as a biomarker of poor short-term prognosis in ischemic stroke Biosci. Rep., 2018;0(0):. 2018 [PMID: 30038059] (Human) Human
M Du, E Phelps, MJ Balangue, A Dockins, G Moiseyev, Y Shin, S Kane, L Otalora, JX Ma, R Farjo, KM Farjo Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration Invest. Ophthalmol. Vis. Sci., 2017;58(10):4095-4103. 2017 [PMID: 28813718] (Mouse) Mouse
G Annibalini, F Lucertini, D Agostini, L Vallorani, A Gioacchini, E Barbieri, M Guescini, L Casadei, A Passalia, M Del Sal, G Piccoli, M Andreani, A Federici, V Stocchi Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients Oxid Med Cell Longev, 2017;2017(0):3937842. 2017 [PMID: 28713486] (Human) Human
S Karunanith, L Levi, J DeVecchio, G Karagkouni, O Reizes, JD Lathia, MF Kalady, N Noy RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis Stem Cell Reports, 2017;0(0):. 2017 [PMID: 28689994] (Human) Human
JL Hurwitz, BG Jones, RR Penkert, S Gansebom, Y Sun, L Tang, AM Bramley, S Jain, JA McCullers, SR Arnold Low Retinol-Binding Protein and Vitamin D Levels Are Associated with Severe Outcomes in Children Hospitalized with Lower Respiratory Tract Infection and Respiratory Syncytial Virus or Human Metapneumovirus Detection J. Pediatr., 2017;0(0):. 2017 [PMID: 28578159] (Human) Human
M Du, A Martin, F Hays, J Johnson, RA Farjo, KM Farjo Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4 Mol. Vis., 2017;23(0):185-197. 2017 [PMID: 28400700] (Mouse) Mouse
Talsma E, Verhoef H, Brouwer I, Mburu-de Wagt A, Hulshof P, Melse-Boonstra A Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study. BMC Med, 2015;13(0):30. 2015 [PMID: 25856672] (Human) Human
Show All 15 Publications.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for RBP4/Retinol-Binding Protein 4 (DRB400). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DRB400

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Bioinformatics Tool for RBP4/Retinol-Binding Protein 4 (DRB400)

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Bioinformatics

Gene Symbol RBP4