Human NT-3 DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Human NT-3 DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
NTF3

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY267.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human NT-3 DuoSet ELISA, 15 Plate

  • HDNF
  • MGC129711
  • Nerve growth factor 2
  • Neurotrophic factor
  • neurotrophin 3
  • neurotrophin-3
  • NGF2
  • NGF-2
  • NT3
  • NT-3
  • NTF3

Background

Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins. All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive NT-3 is predicted to be a noncovalently linked homodimer.

Human NT-3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT-3. The amino acid sequence of mature NT-3 is identical in human, mouse, and rat. NT-3 transcripts have been detected in the cerebellum, hippocampus, placenta, heart, skin, and skeletal muscle. NT-3 primarily activates the TrkC tyrosine kinase receptor. In addition, NT-3 can activate Trk and TrkB kinase receptors in certain cell systems. NT-3 can also bind with low affinity to the low affinity NGF receptor.

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Publications for NT-3 (DY267)(15)

We have publications tested in 2 confirmed species: Human, Rat.


Filter By Application
All Applications
Filter By Species
Human
(11)
Rat
(2)
All Species
Showing Publications 1 - 10 of 15. Show All 15 Publications.
Publications using DY267 Applications Species
HL Lee, CE Yeum, H Lee, J Oh, JT Kim, WJ Lee, Y Ha, YI Yang, KN Kim Peripheral Nerve-Derived Stem Cell Spheroids Induce Functional Recovery and Repair after Spinal Cord Injury in Rodents International Journal of Molecular Sciences, 2021;22(8):. 2021 [PMID: 33923671] (Human) Human
KM Prautsch, A Schmidt, V Paradiso, DJ Schaefer, R Guzman, DF Kalbermatt, S Madduri Modulation of Human Adipose Stem Cells' Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro Cells, 2020;9(9):. 2020 [PMID: 32839392] (Human) Human
Q Han, JD Ordaz, NK Liu, Z Richardson, W Wu, Y Xia, W Qu, Y Wang, H Dai, YP Zhang, CB Shields, GM Smith, XM Xu Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice Nat Commun, 2019;10(1):5815. 2019 [PMID: 31862889] (Human) Human
H Li, Z Yang, W Wang, J Wang, J Zhang, J Liu, T Yang, Y Yang, J Wei, D Lei, X Yang NT-3/TrkC Axis Contributes to the Perineural Invasion and the Poor Prognosis in Human Salivary Adenoid Cystic Carcinoma J Cancer, 2019;10(24):6065-6073. 2019 [PMID: 31762816]
U Milbreta, J Lin, C Pinese, W Ong, JS Chin, H Shirahama, R Mi, A Williams, ME Bechler, J Wang, C Ffrench-Co, A Hoke, SY Chew Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination Mol. Ther., 2018;0(0):. 2018 [PMID: 30611662]
Y Zeng, H Han, B Tang, J Chen, D Mao, M Xiong Transplantation of Recombinant Vascular Endothelial Growth Factor (VEGF)189-Neural Stem Cells Downregulates Transient Receptor Potential Vanilloid 1 (TRPV1) and Improves Motor Outcome in Spinal Cord Injury Med. Sci. Monit., 2018;24(0):1089-1096. 2018 [PMID: 29466323] (Rat) Rat
Cynthia Azeredo Cordeiro Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis Braz J Infect Dis, 2016;0(0):. 2016 [PMID: 27932287] (Human) Human
Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis Cell Rep, 2016;16(11):2928-39. 2016 [PMID: 27626663] (Human) Human
Yao , L, Daly , W, Newland , B, Yao , S, Wang , W, Chen , B K K, Madigan , N, Windebank , A, Pandit , A Improved axonal regeneration of transected spinal cord mediated by multichannel collagen conduits functionalized with neurotrophin-3 gene. Gene Ther, 2013;20(12):1149-57. 2013 [PMID: 23883961] (Human) Human
Jones JL, Anderson JM, Phuah CL, Fox EJ, Selmaj K, Margolin D, Lake SL, Palmer J, Thompson SJ, Wilkins A, Webber DJ, Compston DA, Coles AJ Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain, 2010;133(0):2232-47. 2010 [PMID: 20659956] (Human) Human
Show All 15 Publications.

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Bioinformatics

Gene Symbol NTF3