The Quantikine Human MBL immunoassay is a 4.5 hour solid phase ELISA designed to measure human MBL in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human MBL and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human MBL showed dose-response curves that were parallel to the standard curves obtained using the Qu...antikine kit standards. These results indicate that this kit can be used to determine relative mass values of naturally occurring human MBL.
Oligomeric forms of natural and recombinant human MBL
Mannan binding lectin (MBL) belongs to the collectin family of innate immune defense proteins, which bind an array of carbohydrate patterns on pathogen surfaces. Collectin family members share several common structural features including a N-terminal, cysteine-rich domain, a collagen-like region, an alpha-helical coiled-coil neck domain and a C-terminal, C-type (Ca2+-dependent ) lectin or carbohydrate recognition domain. MBL homotrimerizes to form a structural unit joined by N-terminal disulfide bonds. These homotrimers further associate into oligomeric structures of up to six units.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.