Human IL-18/IL-1F4 ELISA


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Product Details

Reactivity HuSpecies Glossary
Applications ELISA

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Human IL-18/IL-1F4 ELISA Summary

Additional Information
Human IL-18/IL-1F4 Quantikine ELISA Kit is now available!
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
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Application Notes
No significant interference observed with available related molecules.
Read Publications using 7620.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-18/IL-1F4 ELISA

  • Iboctadekin
  • IFN-gamma-inducing factor
  • IGIF
  • IGIFIL-1 gamma
  • IL18
  • IL-18
  • IL-18MGC12320
  • IL-1F4
  • IL1F4iboctadekin
  • IL-1g
  • Interferon gamma-inducing factor
  • interleukin 18 (interferon-gamma-inducing factor)
  • Interleukin-1 gamma
  • interleukin-18


M-CSF, also known as CSF-1, is a four-alpha-helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M-CSF is also essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis. M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta. Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells. The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF can circulate, it may be immobilized by attachment to type V collagen. Shorter transcripts encode M-CSF that lack cleavage and PG sites and produce an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer. Although forms may vary in activity and half-life, all contain the N-terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor. The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat M-CSF, respectively. Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

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Publications for IL-18/IL-1F4 (7620)(39)

We have publications tested in 3 confirmed species: Human, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque).

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Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Primate - Macaca mulatta (Rhesus Macaque)
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Showing Publications 1 - 10 of 39. Show All 39 Publications.
Publications using 7620 Applications Species
X Liu, X Jin, B Chen, X Liu, X Liang, X Fang, H Wu, X Fu, H Zheng, X Ding, N Duan, Y Zhang Effects of Kudiezi Injection on Serum Inflammatory Biomarkers in Patients with Acute Cerebral Infarction Dis. Markers, 2018;2018(0):7936736. 2018 [PMID: 30245755] (Human) Human
Y Torii, JI Kawada, T Murata, H Yoshiyama, H Kimura, Y Ito Epstein-Barr virus infection-induced inflammasome activation in human monocytes PLoS ONE, 2017;12(4):e0175053. 2017 [PMID: 28369146] (Human) Human
EH Ji, C Diep, T Liu, H Li, R Merrill, D Messadi, S Hu Potential protein biomarkers for burning mouth syndrome discovered by quantitative proteomics Mol Pain, 2017;13(0):1744806916686. 2017 [PMID: 28326926] (Human) Human
Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome Int J Mol Sci, 2016;17(8):. 2016 [PMID: 27527149] (Human) Human
Rickettsia australis Activates Inflammasome in Human and Murine Macrophages PLoS ONE, 2016;11(6):e0157231. 2016 [PMID: 27362650] (Human) Human
Han S, Lear T, Jerome J, Rajbhandari S, Snavely C, Gulick D, Gibson K, Zou C, Chen B, Mallampalli R Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase. J Biol Chem, 2015;290(29):18124-33. 2015 [PMID: 26037928] (Human) Human
Jo J, Tan A, Ussher J, Sandalova E, Tang X, Tan-Garcia A, To N, Hong M, Chia A, Gill U, Kennedy P, Tan K, Lee K, De Libero G, Gehring A, Willberg C, Klenerman P, Bertoletti A Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver. PLoS Pathog, 2014;10(6):e1004210. 2014 [PMID: 24967632] (Human) Human
Ikeda T, Kasai M, Tatsukawa E, Kamitakahara M, Shibata Y, Yokoi T, Nemoto T, Ioku K A bone substitute with high affinity for vitamin D-binding protein--relationship with niche of osteoclasts. J Cell Mol Med, 2014;18(1):170-80. 2014 [PMID: 24286277] (Human) Human
Matteini A, Li J, Lange E, Tanaka T, Lange L, Tracy R, Wang Y, Biggs M, Arking D, Fallin M, Chakravarti A, Psaty B, Bandinelli S, Ferrucci L, Reiner A, Walston J Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. Cytokine, 2014;65(1):10-6. 2014 [PMID: 24182552] (Human) Human
Rossetto, Cyprian, Tarrant-Elorza, Margaret, Verma, Subhash, Purushothaman, Pravinku, Pari, Gregory Regulation of viral and cellular gene expression by Kaposi's sarcoma-associated herpes virus polyadenylated nuclear RNA. J Virol, 2013;87(10):5540-53. 2013 [PMID: 23468496] (Human) Human
Show All 39 Publications.

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FAQs for IL-18/IL-1F4 (7620). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.
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Gene Symbol IL18