Human IL-18/IL-1F4 ELISA

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human IL-18/IL-1F4 ELISA Summary

• Additional Information: Human IL-18/IL-1F4 Quantikine ELISA Kit is now available!
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL18

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-18/IL-1F4 ELISA

• Iboctadekin
• IFN-gamma-inducing factor
• IGIF
• IGIFIL-1 gamma
• IL18
• IL-18
• IL-18MGC12320
• IL-1F4
• IL1F4iboctadekin
• IL-1g
• Interferon gamma-inducing factor
• interleukin 18 (interferon-gamma-inducing factor)
• Interleukin-1 gamma
• interleukin-18

Background

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1γ, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-γ and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-γ that inhibits IgE production.

Publications for IL-18/IL-1F4 (7620)(43)

Publications using 7620

• C Udjus, I Sjaastad, U Hjørnholm, TK Tunestveit, P Hoffmann, A Hinojosa, EKS Espe, G Christense, OH Skjønsberg, KO Larsen, M Rostrup Extreme altitude induces divergent mass reduction of right and left ventricle in mountain climbers Physiological Reports, 2022-02-01;10(3):e15184. 2022-02-01 [PMID: 35146955] (Human)
• S Sukhanov, Y Higashi, T Yoshida, S Mummidi, AR Aroor, J Jeffrey Ru, SB Bender, VG DeMarco, B Chandrasek The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1&beta and IL-18 secretion Cell Signal, 2020-11-04;77(0):109825. 2020-11-04 [PMID: 33160017] (Human)
• X Liu, X Jin, B Chen, X Liu, X Liang, X Fang, H Wu, X Fu, H Zheng, X Ding, N Duan, Y Zhang Effects of Kudiezi Injection on Serum Inflammatory Biomarkers in Patients with Acute Cerebral Infarction Dis. Markers, 2018-09-02;2018(0):7936736. 2018-09-02 [PMID: 30245755] (Human)
• Y Torii, JI Kawada, T Murata, H Yoshiyama, H Kimura, Y Ito Epstein-Barr virus infection-induced inflammasome activation in human monocytes PLoS ONE, 2017-04-03;12(4):e0175053. 2017-04-03 [PMID: 28369146] (Human)
• EH Ji, C Diep, T Liu, H Li, R Merrill, D Messadi, S Hu Potential protein biomarkers for burning mouth syndrome discovered by quantitative proteomics Mol Pain, 2017-01-01;13(0):1744806916686. 2017-01-01 [PMID: 28326926] (Human)
• Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome Int J Mol Sci, 2016-08-03;17(8):. 2016-08-03 [PMID: 27527149] (Human)
• Rickettsia australis Activates Inflammasome in Human and Murine Macrophages PLoS ONE, 2016-06-30;11(6):e0157231. 2016-06-30 [PMID: 27362650] (Human)
• Han S, Lear T, Jerome J, Rajbhandari S, Snavely C, Gulick D, Gibson K, Zou C, Chen B, Mallampalli R Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase. J Biol Chem, 2015-06-02;290(29):18124-33. 2015-06-02 [PMID: 26037928] (Human)
• Jo J, Tan A, Ussher J, Sandalova E, Tang X, Tan-Garcia A, To N, Hong M, Chia A, Gill U, Kennedy P, Tan K, Lee K, De Libero G, Gehring A, Willberg C, Klenerman P, Bertoletti A Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver. PLoS Pathog, 2014-06-26;10(6):e1004210. 2014-06-26 [PMID: 24967632] (Human)
• Gluzman-Poltorak Z, Mendonca S, Vainstein V, Kha H, Basile L Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation. J Hematol Oncol, 2014-04-06;7(0):31. 2014-04-06 [PMID: 24708888] (Primate - Macaca mulatta (Rhesus Macaque))
• Danesh A, Inglis H, Jackman R, Wu S, Deng X, Muench M, Heitman J, Norris P Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro. Blood, 2013-12-12;123(5):687-96. 2013-12-12 [PMID: 24335232] (Human)
• Ikeda T, Kasai M, Tatsukawa E, Kamitakahara M, Shibata Y, Yokoi T, Nemoto T, Ioku K A bone substitute with high affinity for vitamin D-binding protein--relationship with niche of osteoclasts. J Cell Mol Med, 2013-11-28;18(1):170-80. 2013-11-28 [PMID: 24286277] (Human)
• Matteini A, Li J, Lange E, Tanaka T, Lange L, Tracy R, Wang Y, Biggs M, Arking D, Fallin M, Chakravarti A, Psaty B, Bandinelli S, Ferrucci L, Reiner A, Walston J Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. Cytokine, 2013-10-29;65(1):10-6. 2013-10-29 [PMID: 24182552] (Human)
• Rossetto , Cyprian, Tarrant-Elorza , Margaret, Verma , Subhash, Purushothaman , Pravinku, Pari , Gregory Regulation of viral and cellular gene expression by Kaposi's sarcoma-associated herpes virus polyadenylated nuclear RNA. J Virol, 2013-03-06;87(10):5540-53. 2013-03-06 [PMID: 23468496] (Human)
• Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman T, Semnani R Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion. Infect Immun, 2013-02-19;81(5):1420-9. 2013-02-19 [PMID: 23429540] (Human)
• Shimizu M, Yachie A Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages. Cytokine, 2012-06-08;60(1):226-32. 2012-06-08 [PMID: 22682876] (Human)
• Chen TH, Chang CH, Lin CY, Jenq CC, Chang MY, Tian YC, Hung CC, Fang JT, Yang CW, Wen MS, Lin FC, Chen YC Acute kidney injury biomarkers for patients in a coronary care unit: a prospective cohort study. PLoS ONE, 2012-02-22;7(2):e32328. 2012-02-22 [PMID: 22384218] (Human)
• Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamaki J, Punnonen K, Laakso M Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects. Atherosclerosis, 2009-12-02;210(2):536-41. 2009-12-02 [PMID: 20031127] (Human)
• Sallmon H, Hoene V, Weber SC, Dame C Differentiation of human SH-SY5Y neuroblastoma cells by all-trans retinoic acid activates the interleukin-18 system. J. Interferon Cytokine Res., 2010-02-01;30(2):55-8. 2010-02-01 [PMID: 20028206] (Human)
• Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J. Immunol., 2009-12-21;184(3):1642-52. 2009-12-21 [PMID: 20026745] (Human)
• Campillo-Gimenez L, Cumont MC, Fay M, Kared H, Monceaux V, Diop O, Muller-Trutwin M, Hurtrel B, Levy Y, Zaunders J, Dy M, Leite-de-Moraes MC, Elbim C, Estaquier J AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection. J. Immunol., 2009-12-16;184(2):984-92. 2009-12-16 [PMID: 20018630] (Primate - Macaca mulatta (Rhesus Macaque))
• Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis. Mediators Inflamm., 2009-07-22;2009(0):269541. 2009-07-22 [PMID: 19639049] (Human)
• Welsh P, Woodward M, Rumley A, Lowe G Associations of circulating TNFalpha and IL-18 with myocardial infarction and cardiovascular risk markers: the Glasgow Myocardial Infarction Study. Cytokine, 2009-07-05;47(2):143-7. 2009-07-05 [PMID: 19581111] (Human)
• Venkatesan B, Valente AJ, Reddy VS, Siwik DA, Chandrasekar B Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration. Am. J. Physiol. Heart Circ. Physiol., 2009-06-26;297(2):H874-86. 2009-06-26 [PMID: 19561311] (Human)
• Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J. Immunol., 2009-05-15;182(10):6460-9. 2009-05-15 [PMID: 19414800] (Human)
• Yearley JH, Xia D, Pearson CB, Carville A, Shannon RP, Mansfield KG Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol diet. Lab. Invest., 2009-04-20;89(6):657-67. 2009-04-20 [PMID: 19381133] (Primate - Macaca mulatta (Rhesus Macaque))
• Empana JP, Canoui-Poitrine F, Luc G, Juhan-Vague I, Morange P, Arveiler D, Ferrieres J, Amouyel P, Bingham A, Montaye M, Ruidavets JB, Haas B, Evans A, Ducimetiere P Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study. Eur. Heart J., 2008-07-10;29(16):1966-74. 2008-07-10 [PMID: 18621771] (Human)
• Samnegard A, Hulthe J, Silveira A, Ericsson CG, Hamsten A, Eriksson P Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients. Atherosclerosis, 2008-06-05;202(2):550-6. 2008-06-05 [PMID: 18619594] (Human)
• Everett BM, Bansal S, Rifai N, Buring JE, Ridker PM Interleukin-18 and the risk of future cardiovascular disease among initially healthy women. Atherosclerosis, 2008-04-22;202(1):282-8. 2008-04-22 [PMID: 18514203] (Human)
• Yearley JH, Mansfield KG, Carville AA, Sokos GG, Xia D, Pearson CB, Shannon RP Antigenic stimulation in the simian model of HIV infection yields dilated cardiomyopathy through effects of TNFalpha. AIDS, 2008-03-12;22(5):585-94. 2008-03-12 [PMID: 18316999] (Human)
• Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J. Immunol., 2007-02-01;178(3):1948-59. 2007-02-01 [PMID: 17237446] (Human)
• Blankenberg S, Godefroy T, Poirier O, Rupprecht HJ, Barbaux S, Bickel C, Nicaud V, Schnabel R, Kee F, Morrison C, Evans A, Lackner KJ, Cambien F, Munzel T, Tiret L Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk. Circ. Res., 2006-06-15;99(1):102-8. 2006-06-15 [PMID: 16778130] (Human)
• Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin. Cancer Res., 2006-01-15;12(2):376-82. 2006-01-15 [PMID: 16428475] (Human)
• Skurk T, Kolb H, Muller-Scholze S, Rohrig K, Hauner H, Herder C The proatherogenic cytokine interleukin-18 is secreted by human adipocytes. Eur. J. Endocrinol., 2005-06-01;152(6):863-8. 2005-06-01 [PMID: 15941925] (Human)
• Lindberg C, Chromek M, Ahrengart L, Brauner A, Schultzberg M, Garlind A Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease. Neurochem. Int., 2005-06-01;46(7):551-7. 2005-06-01 [PMID: 15843049] (Human)
• Barak V, Elchalal U, Edelstein M, Kalickman I, Lewin A, Abramov Y Interleukin-18 levels correlate with severe ovarian hyperstimulation syndrome. Fertil. Steril., 2004-08-01;82(2):415-20. 2004-08-01 [PMID: 15302292] (Human)
• Grandjean-Laquerriere A, Laquerriere P, Laurent-Maquin D, Guenounou M, Phillips TM The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro. Biomaterials, 2004-12-01;25(28):5921-7. 2004-12-01 [PMID: 15183606] (Human)
• Garofalo RP, Hintz KH, Hill V, Ogra PL, Welliver RC Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18. J. Med. Virol., 2004-06-01;73(2):289-94. 2004-06-01 [PMID: 15122806] (Human)
• Chaiyaroj SC, Rutta AS, Muenthaisong K, Watkins P, Na Ubol M, Looareesuwan S Reduced levels of transforming growth factor-beta1, interleukin-12 and increased migration inhibitory factor are associated with severe malaria. Acta Trop., 2004-02-01;89(3):319-27. 2004-02-01 [PMID: 14744558] (Human)
• Vankayalapati R, Klucar P, Wizel B, Weis SE, Samten B, Safi H, Shams H, Barnes PF NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen. J. Immunol., 2004-01-01;172(1):130-7. 2004-01-01 [PMID: 14688318] (Human)
• Geisbert TW, Hensley LE, Larsen T, Young HA, Reed DS, Geisbert JB, Scott DP, Kagan E, Jahrling PB, Davis KJ Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection. Am. J. Pathol., 2003-12-01;163(6):2347-70. 2003-12-01 [PMID: 14633608] (Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K Cytokine profile in Behcet's disease patients. Relationship with disease activity. Scand. J. Rheumatol., 2002-01-01;31(4):205-10. 2002-01-01 [PMID: 12369651] (Human)
• Pages F, Lebel-Binay S, Vieillefond A, Deneux L, Cambillau M, Soubrane O, Debre B, Tardy D, Lemonne JL, Abastado JP, Fridman WH, Thiounn N Local immunostimulation induced by intravesical administration of autologous interferon-gamma-activated macrophages in patients with superficial bladder cancer. Clin. Exp. Immunol., 2002-02-01;127(2):303-9. 2002-02-01 [PMID: 11876754] (Human)

FAQs for IL-18/IL-1F4 (7620). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: IL18