Human IL-13 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-13 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL13

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-13 DuoSet ELISA, 15 Plate

• ALRHMGC116789
• BHR1interleukin-13
• IL13
• IL-13
• IL-13MGC116788
• interleukin 13
• MGC116786
• NC30
• P600

Background

IL-13 (Interleukin-13) plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. It promotes B cell activation, immunoglobulin class switching to IgE, and the upregulation of CD23/Fc epsilon RII. IL-13 signals through a receptor complex containing IL-13 R alpha 1 and IL-4 R alpha. This complex also functions as the type 2 IL-4 receptor. IL-13 R alpha 2 binds IL-13 and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex. IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis.

Publications for IL-13 (DY213)(26)

Publications using DY213

• Wu, WC;Shiu, C;Tong, TK;Leung, SO;Hui, CW; Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases Journal of immunology research 2023-12-08 [PMID: 38106519] (Human)
• HR Yu, TY Hsu, CC Tsai, HC Huang, HH Cheng, YJ Lai, YJ Lin, CC Chen, SC Li, K Yang The Functional DNA Methylation Signatures Relevant to Altered Immune Response of Neonatal T Cells with l-Arginine Supplementation Nutrients, 2021-08-13;13(8):. 2021-08-13 [PMID: 34444938] (Human)
• SL Mathiasen, L Gall-Mas, IS Pateras, SDP Theodorou, MRJ Namini, MB Hansen, OCB Martin, CK Vadivel, K Ntostoglou, D Butter, M Givskov, C Geisler, AN Akbar, VG Gorgoulis, T Frisan, N Ødum, T Krejsgaard Bacterial genotoxins induce T�cell senescence Cell Reports, 2021-06-08;35(10):109220. 2021-06-08 [PMID: 34107253] (Human)
• M De, A Bhushan, S Chinnaswam Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-&lambda3 or IFN-&lambda4 show distinct phenotypes J Leukoc Biol, 2020-11-17;0(0):. 2020-11-17 [PMID: 33205487] (Human)
• M Herrera, C Vera, Y Keynan, ZV Rueda Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review J Immunol Res, 2020-04-21;2020(0):8074183. 2020-04-21 [PMID: 32377537] (Human)
• Rui Zheng, Yang Chen, Jianbo Shi, Kai Wang, Xuekun Huang, Yueqi Sun et al. Combinatorial IL-17RB, ST2, and TSLPR Signaling in Dendritic Cells of Patients With Allergic Rhinitis Frontiers in Cell and Developmental Biology 2020-04-03 [PMID: 32309281] (Human)
• R Bhardwaj, A Suzuki, P Leland, BH Joshi, RK Puri Identification of a novel role of IL-13R?2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway J Transl Med, 2018-12-20;16(1):369. 2018-12-20 [PMID: 30572904] (Human)
• MA Hjort, H Hov, P Abdollahi, EN Vandsemb, UM Fagerli, B Lund, TS Slørdahl, M Børset, TB Rø Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration Exp Hematol Oncol, 2018-04-10;7(0):8. 2018-04-10 [PMID: 29651360] (Human)
• Gisa Tiegs A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis J. Immunol., 2016-11-21;0(0):. 2016-11-21 [PMID: 27872212] (Human)
• Maryam Salimi, Luzheng Xue, Helen Jolin, Clare Hardman, David J. Cousins, Andrew N. J. McKenzie et al. Group 2 innate lymphoid cells express functional NKp30 receptor inducing type 2 cytokine production1 The Journal of Immunology 2016-01-01 [PMID: 26582946] (Human)
• Guirado E, Mbawuike U, Keiser T, Arcos J, Azad A, Wang S, Schlesinger L Characterization of host and microbial determinants in individuals with latent tuberculosis infection using a human granuloma model. MBio, 2015-02-17;6(1):e02537-14. 2015-02-17 [PMID: 25691598] (Human)
• Arndts , Kathrin, Specht , Sabine, Debrah , Alexande, Tamarozzi , Francesc, Klarmann Schulz , Ute, Mand , Sabine, Batsa , Linda, Kwarteng , Alexande, Taylor , Mark, Adjei , Ohene, Martin , Coralie, Layland , Laura E, Hoerauf , Achim Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels. PLoS Negl Trop Dis, 2014-02-20;8(2):e2679. 2014-02-20 [PMID: 24587458] (Human)
• Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-02-18;44(5):1330-40. 2014-02-18 [PMID: 24549985] (Human)
• Harfuddin Z, Kwajah S, Chong Nyi Sim A, Macary P, Schwarz H CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses. Oncoimmunology, 2013-11-11;2(11):e26859. 2013-11-11 [PMID: 24482752] (Human)
• Cheng K, Wong S, Linn Y, Ho L, Chng W, Schwarz H CD137 ligand signalling induces differentiation of primary acute myeloid leukaemia cells. Br J Haematol, 2014-01-15;165(1):134-44. 2014-01-15 [PMID: 24428589] (Human)
• McHedlidze T, Waldner M, Zopf S, Walker J, Rankin A, Schuchmann M, Voehringer D, McKenzie A, Neurath M, Pflanz S, Wirtz S Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity, 2013-08-15;39(2):357-71. 2013-08-15 [PMID: 23954132] (Human)
• Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti. PLoS Negl Trop Dis, 2012-04-03;6(4):e1611. 2012-04-03 [PMID: 22509424] (Human)
• Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. Clin. Immunol., 2009-06-25;133(1):27-44. 2009-06-25 [PMID: 19559654] (Human)
• Lamhamedi-Cherradi SE, Martin RE, Ito T, Kheradmand F, Corry DB, Liu YJ, Moyle M Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J. Immunol., 2008-05-01;180(9):6000-9. 2008-05-01 [PMID: 18424720] (Human)
• Chen L, Yang P, Zhou H, He H, Ren X, Chi W, Wang L, Kijlstra A Diminished frequency and function of CD4+CD25high regulatory T cells associated with active uveitis in Vogt-Koyanagi-Harada syndrome. Invest. Ophthalmol. Vis. Sci., 2008-04-17;49(8):3475-82. 2008-04-17 [PMID: 18421089] (Human)
• Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood, 2007-09-11;110(13):4319-30. 2007-09-11 [PMID: 17848619] (Human)
• Monick MM, Powers LS, Hassan I, Groskreutz D, Yarovinsky TO, Barrett CW, Castilow EM, Tifrea D, Varga SM, Hunninghake GW Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17. J. Immunol., 2007-08-01;179(3):1648-58. 2007-08-01 [PMID: 17641031] (Human)
• Hilliard TN, Regamey N, Shute JK, Nicholson AG, Alton EW, Bush A, Davies JC Airway remodelling in children with cystic fibrosis. Thorax, 2007-05-25;62(12):1074-80. 2007-05-25 [PMID: 17526676] (Human)
• Plante S, Semlali A, Joubert P, Bissonnette E, Laviolette M, Hamid Q, Chakir J Mast cells regulate procollagen I (alpha 1) production by bronchial fibroblasts derived from subjects with asthma through IL-4/IL-4 delta 2 ratio. J. Allergy Clin. Immunol., 2006-02-21;117(6):1321-7. 2006-02-21 [PMID: 16750993] (Human)
• Chavarria A, Fleury A, Bobes RJ, Morales J, Fragoso G, Sciutto E A depressed peripheral cellular immune response is related to symptomatic neurocysticercosis. Microbes Infect., 2006-01-19;8(4):1082-9. 2006-01-19 [PMID: 16520076] (Human)
• de Jesus AR, Magalhaes A, Miranda DG, Miranda RG, Araujo MI, de Jesus AA, Silva A, Santana LB, Pearce E, Carvalho EM Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection. Infect. Immun., 2004-06-01;72(6):3391-7. 2004-06-01 [PMID: 15155645] (Human)

FAQs for IL-13 (DY213). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: IL13