Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human IL-1 beta/IL-1F2 Quantikine ELISA Kit Summary

• Background: The Quantikine Human IL-1 beta Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure IL-1 beta in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-1 beta and antibodies raised against the recombinant factor. It has been shown to quantitate recombinant human IL-1 beta accurately. Results obtained using natural IL-1 beta s...howed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural IL-1 beta. Reports indicate that this and other ELISA kits calibrated using mature IL-1 beta as a standard will detect, but considerably underestimate, the unprocessed IL-1 beta precursor present in samples. In biological samples other than cell lysates, the precursor form of IL-1 beta is usually not the predominant form of IL-1 beta present and, additionally, is not biologically active. Therefore, results obtained using this kit should provide a useful measure of the levels of active IL-1 beta present in biological fluids.
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• Specificity: Natural and recombinant human IL-1 beta
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL1B

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-1 beta/IL-1F2 Quantikine ELISA Kit

• catabolin
• IL1 beta
• IL-1 beta
• IL-1
• IL1B
• IL-1b
• IL1-BETA
• IL-1F2
• IL1F2IL-1 beta
• interleukin 1, beta
• interleukin-1 beta
• preinterleukin 1 beta
• pro-interleukin-1-beta

Background

The Interleukin 1 (IL-1) family of proteins consists of the classic members IL-1 alpha , IL-1 beta , and IL-1ra, plus IL-18, IL-33 and IL-1F5-F10. IL-1 alpha and IL-1 beta bind to the same cell surface receptors and share biological functions. IL-1 is not produced by unstimulated cells of healthy individuals with the exception of skin keratinocytes, some epithelial cells, and certain cells of the central nervous system. However, in response to inflammatory agents, infections, or microbial endotoxins, a dramatic increase in the production of IL-1 by macrophages and various other cell types is observed. IL-1 beta plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. Inappropriate or prolonged production of IL-1 has been implicated in a variety of pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. 

 IL-1 alpha and IL-1 beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both are synthesized as 31 kDa precursors that are subsequently cleaved into mature proteins of approximately 17.5 kDa. Cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. Neither IL-1 alpha nor IL-1 beta contains a typical hydrophobic signal peptide, but evidence suggests that these factors can be secreted by non-classical pathways. A portion of unprocessed IL-1 alpha can be presented on the cell membrane and may retain biological activity. The precursor form of IL-1 beta , unlike the IL-1 alpha precursor, shows little or no biological activity in comparison to the processed form. Both unprocessed and mature forms of IL-1 beta are exported from the cell. 

 IL-1 alpha and IL-1 beta exert their effects through immunoglobulin superfamily receptors that additionally bind IL-1ra. The 80 kDa transmembrane type I receptor (IL-1 RI) is expressed on T cells, fibroblasts, keratinocytes, endothelial cells, synovial lining cells, chondrocytes, and hepatocytes. The 68 kDa transmembrane type II receptor (IL-1 RII) is expressed on B cells, neutrophils, and bone marrow cells. The two IL-1 receptor types show approximately 28% homology in their extracellular domains but differ significantly in that the type II receptor has a cytoplasmic domain of only 29 amino acids (aa), whereas the type I receptor has a 213 aa cytoplasmic domain. IL-1 RII does not appear to signal in response to IL-1 and may function as a decoy receptor that attenuates IL-1 function. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction. IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1. Soluble forms of both IL-1 RI and IL-1 RII have been detected in human plasma, synovial fluids, and the conditioned media of several human cell lines. In addition, IL-1 binding proteins that resemble soluble IL-1 RII are encoded by vaccinia and cowpox viruses.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-1 beta/IL-1F2 (DLB50)(351)

Publications using DLB50

• Mulè, S;Galla, R;Ferrari, S;Invernizzi, M;Uberti, F; Molecular Insights into the Nociceptive Modulation by Palmitoylethanolamide and Equisetum arvense Extract: An In Vitro Study Across the Blood-Brain Barrier Nutrients 2025-06-13 [PMID: 40573109] (Human)
• Lee, S;Lim, CK;Kim, J;Kim, J;Jin, HK;Bae, JS;Jeon, JW; Engagement of CD300c by a Novel Monoclonal Antibody Ameliorates Behavioral Deficits in a 5xFAD Mouse Model of Alzheimer's Disease Biomedicines 2025-05-10 [PMID: 40426995] (Human)
• Li, HH;Liu, X;Wang, YP;Xu, X;Zhu, L;Zhang, W;Ren, K; Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway Metabolites 2025-05-15 [PMID: 40422906] (Human)
• Chen, M;Guo, G;Liu, S;Cai, J;Tong, X;Liu, X;Zhang, Y;Chen, Y;Huo, J; Investigating the relationship between sleep disturbances and cortical thickness, brainstem volume, amyloid accumulation, and inflammatory markers in Parkinson's disease patients Experimental gerontology 2025-04-17 [PMID: 40252714] (Human)
• Srakhao, W;Nakpheng, T;Mohd Amin, MCI;Srichana, T; Therapeutic Potential of Cannabidiol Cyclodextrin Complex in Polymeric Micelle and Tetrahydrocurcumin Cyclodextrin Complex Loaded in Hydrogel to Treat Lymphedema International journal of molecular sciences 2025-04-06 [PMID: 40244338] (Human)
• Kim, J;Moon, SY;Kang, HG;Kim, HJ;Choi, JS;Lee, SHS;Park, K;Won, SY; Therapeutic potential of AAV2-shmTOR gene therapy in reducing retinal inflammation and preserving endothelial Integrity in age-related macular degeneration Scientific reports 2025-03-19 [PMID: 40108376] (Human)
• Sánchez, M;Mercader Ruiz, J;Marijuán Pinel, D;Sánchez, P;Fiz, N;Guadilla, J;Azofra, J;Beitia, M;Delgado, D; Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration Scientific reports 2025-02-06 [PMID: 39915642] (Human)
• Toney, NJ;Opdenaker, LM;Frerichs, L;Modarai, SR;Ma, A;Archinal, H;Ajayi, GO;Sims-Mourtada, J; B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer Scientific reports 2025-01-16 [PMID: 39820772] (Human)
• Sarmin, M;Akter, F;Islam, AN;Mahfuz, M;Das, S;Sharifuzzaman, ;Hasan, SMT;Bhuiyan, TR;Rahman, M;Gazi, A;Matin, FB;Tariqujjaman, M;Shahrin, L;Islam, M;Mahmud, AM;Banu, S;Chisti, MJ;Qadri, F;Clemens, JD;Ahmed, T; Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort study Heliyon 2024-12-15 [PMID: 39654713] (Human)
• Kawasaki, R;Sakata, A;Tatsumi, K;Mitani, S;Takeda, M;Kasuda, S;Matsumoto, N;Harada, S;Soeda, T;Nishida, Y;Yoshimura, Y;Shima, M; ?-hydroxybutyrate suppresses pathological changes of blood-induced arthropathy in rats Scientific reports 2024-11-29 [PMID: 39614095] (Human)
• Song, D;Cen, Y;Qian, Z;Wu, XS;Rivera, K;Wee, TL;Demerdash, OE;Chang, K;Pappin, D;Vakoc, CR;Tonks, NK; PTPN23-dependent ESCRT machinery functions as a cell death checkpoint Nature communications 2024-11-28 [PMID: 39609437] (Human)
• Li, X;Yan, Y;Wang, Z;Hou, J;Meng, Y;Cui, D;Long, Y;Li, M;Yang, R; The link between osteoporosis and frozen shoulder: exploring the therapeutic effect of TAK715 on reversing fibrosis and protecting against osteoporosis via the p38 MAPK signaling pathway BMC musculoskeletal disorders 2024-11-21 [PMID: 39574076] (Human)
• Kazemi-Sufi, S;Alipour, S;Rabieepour, M;Roshan-Milani, S;Naderi, R; Serum proinflammatory cytokines, receptor activator of nuclear factor kappa-? ligand (RANKL), osteoprotegerin (OPG) and RANKL/OPG ratio in mild and severe COVID-19 BMC infectious diseases 2024-09-27 [PMID: 39333916] (Human)
• Wackerbarth, LM;Seifert, SB;Napoli, M;Rohwedder, I;Vogl, T;Scheiermann, C;Kolben, T;Nussbaum, C;Pruenster, M;Immler, R;Sperandio, M; Neonatal neutrophils exhibit reduced NLRP3 inflammasome activation Journal of leukocyte biology 2024-09-23 [PMID: 39312228] (Human)
• Longo, M;Paolini, E;Di Benedetto, P;Tomassini, E;Meroni, M;Dongiovanni, P; DGAT1 and DGAT2 Inhibitors for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management: Benefits for Their Single or Combined Application International journal of molecular sciences 2024-08-21 [PMID: 39201759] (Human)
• Song, M;Deng, M;Peng, Z;Dai, F;Wang, Y;Shu, W;Zhou, X;Zhang, J;Hou, Y;Yu, B; Granulocyte colony-stimulating factor mediates bone loss via the activation of IL-1?/JNK signaling pathway in murine Staphylococcus aureus-induced osteomyelitis International immunopharmacology 2024-08-19 [PMID: 39163688] (Mouse)
• Franco-De León, K;Camarena, EE;Pereira-Suárez, AL;Barrios-Prieto, E;Soto-Venegas, A;Hernández-Nazara, ZH;Luna Rojas, YG;Galván-Ramírez, ML; Interleukins IL33/ST2 and IL1-? in Intrauterine Growth Restriction and Seropositivity of Anti-Toxoplasma gondii Antibodies Microorganisms 2024-07-12 [PMID: 39065188] (Human)
• Sun, Y;Lu, Y;Liu, L;Saaoud, F;Shao, Y;Xu, K;Drummer Iv, C;Cueto, R;Shan, H;Jiang, X;Zhao, H;Wang, H;Yang, X; Caspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity JCI insight 2024-07-18 [PMID: 39024553] (Human)
• Kutuk, MO;Tufan, AE;Kilicaslan, F;Gokcen, C;Aksu, GG;Yektas, C;Kandemir, H;Celik, F;Mutluer, T;Buber, A;Karadag, M;Coban, N;Coskun, S;Hangul, Z;Altintas, E;Acikbas, U;Giray, A;Aka, Y;Basturk, B;Kutuk, O; Cytokine expression profiles in children and adolescents with tic disorders Scientific reports 2024-07-02 [PMID: 38956051] (Human)
• Kim, H;Park, HH;Kim, HN;Seo, D;Hong, KS;Jang, JG;Seo, EU;Kim, IY;Jeon, SY;Son, B;Cho, SW;Kim, W;Ahn, JH;Lee, W; The TOX-RAGE axis mediates inflammatory activation and lung injury in severe pulmonary infectious diseases Proceedings of the National Academy of Sciences of the United States of America 2024-06-25 [PMID: 38900789] (Human)
• Kim, MJ;Ahn, HJ;Kong, D;Lee, S;Kim, DH;Kang, KS; Modeling of solar UV-induced photodamage on the hair follicles in human skin organoids Journal of tissue engineering 2024-05-08 [PMID: 38725732] (Human)
• Lee, JY;Kang, Y;Jeon, JY;Kim, HJ;Kim, DJ;Lee, KW;Han, SJ; Imeglimin attenuates NLRP3 inflammasome activation by restoring mitochondrial functions in macrophages Journal of pharmacological sciences 2024-06-01 [PMID: 38677784] (Human)
• Scovino, AM;Dahab, EC;Diniz-Lima, I;de Senna Silveira, E;Barroso, SPC;Cardoso, KM;Nico, D;Makhoul, GJ;da Silva-Junior, EB;Freire-de-Lima, CG;Freire-de-Lima, L;Fonseca, LMD;Valente, N;Nacife, V;Machado, A;Araújo, M;Vieira, GF;Pauvolid-Corrêa, A;Siqueira, M;Morrot, A; A Comparative Analysis of Innate Immune Responses and the Structural Characterization of Spike from SARS-CoV-2 Gamma Variants and Subvariants Microorganisms 2024-04-02 [PMID: 38674664] (Human)
• Melgar-Rodríguez, S;Polanco, A;Ríos-Muñoz, J;García, M;Sierra-Cristancho, A;González-Osuna, L;Díaz-Zúñiga, J;Carvajal, P;Vernal, R;Bravo, D; Differential Response of Human Dendritic Cells upon Stimulation with Encapsulated or Non-Encapsulated Isogenic Strains of Porphyromonas gingivalis International journal of molecular sciences 2024-04-20 [PMID: 38674095] (Human)
• March, S;Nerurkar, N;Jain, A;Andrus, L;Kim, D;Whittaker, CA;Tan, EKW;Thiberge, S;Fleming, HE;Mancio-Silva, L;Rice, CM;Bhatia, SN; Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses Science advances 2024-04-26 [PMID: 38657074] (Human)
• Onodera, T;Iwasaki, K;Matsuoka, M;Morioka, Y;Matsubara, S;Kondo, E;Iwasaki, N; The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty Scientific reports 2024-04-18 [PMID: 38637604] (ELISA, Human)
• Olar, MP;Iacobescu, M;Bolboac?, SD;Pojoga, C;Mo?teanu, O;Seicean, R;Rusu, I;Banc, O;Iuga, CA;Seicean, A; Neutrophil Gelatinase-Associated Lipocalin for the Differentiation of Mucinous Pancreatic Cystic Lesions International journal of molecular sciences 2024-03-12 [PMID: 38542201] (Human)
• Hasegawa, T;Noguchi, S;Nakashima, M;Miyai, M;Goto, M;Matsumoto, Y;Torii, S;Honda, S;Shimizu, S; Alternative autophagy dampens UVB-induced NLRP3 inflammasome activation in human keratinocytes The Journal of biological chemistry 2024-03-16 [PMID: 38499149] (Human)
• Li, Y;Wu, C;Lee, J;Ning, Q;Lim, J;Eoh, H;Wang, S;Hurrell, BP;Akbari, O;Ou, JJ; Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages PLoS pathogens 2024-03-11 [PMID: 38466743] (Human)
• Tsukalov, I;Sánchez-Cerrillo, I;Rajas, O;Avalos, E;Iturricastillo, G;Esparcia, L;Buzón, MJ;Genescà, M;Scagnetti, C;Popova, O;Martin-Cófreces, N;Calvet-Mirabent, M;Marcos-Jimenez, A;Martínez-Fleta, P;Delgado-Arévalo, C;de Los Santos, I;Muñoz-Calleja, C;Calzada, MJ;González Álvaro, I;Palacios-Calvo, J;Alfranca, A;Ancochea, J;Sánchez-Madrid, F;Martin-Gayo, E; NF?B and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins Nature communications 2024-03-07 [PMID: 38453949] (Human)
• Tamagawa, S;Sakai, D;Nojiri, H;Nakamura, Y;Warita, T;Matsushita, E;Schol, J;Soma, H;Ogasawara, S;Munesada, D;Koike, M;Shimizu, T;Sato, M;Ishijima, M;Watanabe, M; SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential Redox biology 2024-02-19 [PMID: 38412803] (Human)
• Kosmider, O;Possémé, C;Templé, M;Corneau, A;Carbone, F;Duroyon, E;Breillat, P;Chirayath, TW;Oules, B;Sohier, P;Luka, M;Gobeaux, C;Lazaro, E;Outh, R;Le Guenno, G;Lifermann, F;Berleur, M;Le Mene, M;Friedrich, C;Lenormand, C;Weitten, T;Guillotin, V;Burroni, B;Boussier, J;Willems, L;Aractingi, S;Dionet, L;Tharaux, PL;Vergier, B;Raynaud, P;Ea, HK;Ménager, M;Duffy, D;Terrier, B; VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation Nature communications 2024-01-30 [PMID: 38291039] (Human)
• Chiu, HW;Lee, HL;Lee, HH;Lu, HW;Lin, KY;Lin, YF;Lin, CH; AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-?B activation in oral squamous cell carcinoma Journal of translational medicine 2024-01-03 [PMID: 38166970] (Human)
• Mochizuki, T;Ushiki, T;Suzuki, K;Sato, M;Ishiguro, H;Suwabe, T;Watanabe, S;Edama, M;Omori, G;Yamamoto, N;Kawase, T; Elevated IL-1? and Comparable IL-1 Receptor Antagonist Levels Are Characteristic Features of L-PRP in Female College Athletes Compared to Male Professional Soccer Players International journal of molecular sciences 2023-12-14 [PMID: 38139317] (Human)
• Park, YJ;Acosta, D;Rubel Hoq, M;Khurana, S;Golding, H;Zaitseva, M; Pyrogenic and inflammatory mediators are produced by polarized M1 and M2 macrophages activated with D-dimer and SARS-CoV-2 spike immune complexes Cytokine 2024-01-01 [PMID: 38041875] (Human)
• Jin, Y;Zhang, D;Deng, K;Wu, P;Yang, D;Xie, Z;Qiu, W;Yu, G; Role of the cAMP-PKA-NF-?B pathway in Mucin1 over-expression in A549 cells during Respiratory syncytial virus infection BMC infectious diseases 2023-11-30 [PMID: 38036963] (Human)
• Nabatanzi, R;Ssekamatte, P;Castelnuovo, B;Kambugu, A;Nakanjako, D; Increased Levels of Caspase-1 and IL-1? Among Adults With Persistent Immune Activation After 12 Years of Suppressive Antiretroviral Therapy in the Infectious Diseases Institute HIV Treatment Cohort Open forum infectious diseases 2023-11-01 [PMID: 37953818] (Human)
• Ur Rahim, J;Faheem, MM;Nawaz, S;Goswami, A;Rai, R; Synthesis and characterization of piperic acid conjugates with homochiral and heterochiral dipeptides containing phenylalanine and their application in skin cancer Peptides 2023-11-03 [PMID: 37923167] (Mouse)
• Bok, EY;Kim, SB;Thakur, G;Choe, YH;Oh, SJ;Hwang, SC;Ock, SA;Rho, GJ;Lee, SI;Lee, WJ;Lee, SL; Insensitive Effects of Inflammatory Cytokines on the Reference Genes of Synovial Fluid Resident-Mesenchymal Stem Cells Derived from Rheumatoid Arthritis Patients International journal of molecular sciences 2023-10-13 [PMID: 37894839] (Human)
• Pleros, C;Adamidis, K;Kantartzi, K;Griveas, I;Baltsavia, I;Moustakas, A;Kalliaropoulos, A;Fraggedaki, E;Petra, C;Damianakis, N;Mentis, A;Drosataki, E;Petrakis, I;Passadakis, P;Panagopoulos, P;Stylianou, K;Panagoutsos, S; Dialysis Patients Respond Adequately to Influenza Vaccination Irrespective of Dialysis Modality and Chronic Inflammation Journal of clinical medicine 2023-09-26 [PMID: 37834849] (Human)
• Ma?uj?o-Balcerska, E;Pietras, T; Deiodinase Types 1 and 3 and Proinflammatory Cytokine Values May Discriminate Depressive Disorder Patients from Healthy Controls Journal of clinical medicine 2023-09-24 [PMID: 37834806] (Human)
• Krug, J;Bochenek, ML;Gogiraju, R;Laubert-Reh, D;Lackner, KJ;Münzel, T;Wild, PS;Espinola-Klein, C;Schäfer, K; Circulating Soluble EPCR Levels Are Reduced in Patients with Ischemic Peripheral Artery Disease and Associated with Markers of Endothelial and Vascular Function Biomedicines 2023-09-04 [PMID: 37760900] (Human)
• Mochizuki, T;Ushiki, T;Suzuki, K;Sato, M;Ishiguro, H;Suwabe, T;Edama, M;Omori, G;Yamamoto, N;Kawase, T; Characterization of Leukocyte- and Platelet-Rich Plasma Derived from Female Collage Athletes: A Cross-Sectional Cohort Study Focusing on Growth Factor, Inflammatory Cytokines, and Anti-Inflammatory Cytokine Levels International journal of molecular sciences 2023-09-02 [PMID: 37686398] (Human)
• Dai, B;Cao, H;Hu, Y;Gong, Z;Huang, X;Chen, Y;Liu, F;Peng, X;Zhang, Y;Lei, X; Role of NLRP3 inflammasome activation in HCC cell progression Heliyon 2023-09-01 [PMID: 37681160] (Human)
• Grigalevi?i?t?, R;Matusevi?ius, P;Plan?i?nien?, R;Stankevi?ius, R;Radzevi?i?t?-Val?iuk?, E;Balevi?i?t?, A;Želvys, A;Zinkevi?ien?, A;Zigmantait?, V;Ku?inskas, A;Kavaliauskas, P; Understanding the Immunomodulatory Effects of Bovine Colostrum: Insights into IL-6/IL-10 Axis-Mediated Inflammatory Control Veterinary sciences 2023-08-11 [PMID: 37624306] (Human)
• Kang, YJ;Diep, YN;Tran, M;Tran, VTA;Ambrin, G;Ngo, H;Cho, H; Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration Nature protocols 2023-08-04 [PMID: 37542184] (Human)
• Zhang, X;Yao, J;Li, X;Niu, N;Liu, Y;Hajek, RA;Peng, G;Westin, S;Sood, AK;Liu, J; Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer Science advances 2023-07-21 [PMID: 37478190] (Human)
• Wakasugi-Onogi, S;Ma, S;Ruhee, RT;Tong, Y;Seki, Y;Suzuki, K; Sulforaphane Attenuates Neutrophil ROS Production, MPO Degranulation and Phagocytosis, but Does Not Affect NET Formation Ex Vivo and In Vitro International journal of molecular sciences 2023-05-09 [PMID: 37239829] (Human)
• H Alsayed, IA Bukhari, R Alsaif, F Vohra Efficacy of indocyanine green and methylene blue mediated-photodynamic therapy on peri-implant outcomes among diabetics with peri-implant mucositis Photodiagnosis and photodynamic therapy, 2023-02-24;42(0):103344. 2023-02-24 [PMID: 36841279] (Human)
• L Ostrowska, J Smarkusz-Z, A Gornowicz, K Lendzion, B Zy?k, D Pogodzi?sk Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity-A Pilot Study International Journal of Molecular Sciences, 2023-02-18;24(4):. 2023-02-18 [PMID: 36835557] (Human)
• B Zy?k, L Ostrowska, J Smarkusz-Z, K Witczak-Sa, A Gornowicz, A Bielawska Pro-Inflammatory Adipokine and Cytokine Profiles in the Saliva of Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)-A Pilot Study International Journal of Molecular Sciences, 2023-02-02;24(3):. 2023-02-02 [PMID: 36769216] (Human)
• H Hallihan, P Tsai, N Lv, L Xiao, B Peñalver B, Y Wu, GN Pandey, LM Williams, OA Ajilore, J Ma Affective neural circuits and inflammatory markers linked to depression and anxiety symptoms in patients with comorbid obesity Journal of psychiatric research, 2023-02-03;160(0):9-18. 2023-02-03 [PMID: 36764197] (Human)
• VSMC Correa, NE Efstathiou, DP Ntentakis, Z Yu, T Narimatsu, E Gragoudas, IK Kim, DG Vavvas The NLRP3 inflammasome - Interleukin 1beta axis in uveal melanoma FEBS Open Bio, 2023-02-12;0(0):. 2023-02-12 [PMID: 36707938] (Human)
• Y Nakayama, S Tabe, A Yamaguchi, Y Tsuruya, R Kobayashi, K Oyama, D Kitano, K Kojima, R Kogawa, Y Okumura, J Ogihara, H Senpuku, Y Ogata Identification of Nutritional Factors to Evaluate Periodontal Clinical Parameters in Patients with Systemic Diseases Nutrients, 2023-01-11;15(2):. 2023-01-11 [PMID: 36678235] (Human)
• T Tsai, M Alwees, MA Asaad, J Theile, V Kakkassery, HB Dick, T Schultz, SC Joachim Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy PLoS ONE, 2023-01-20;18(1):e0280488. 2023-01-20 [PMID: 36662891] (Human)
• EL Orth-He, HC Huang, SD Rao, Q Wang, Q Chen, CM O'Mara, AJ Chui, M Saoi, AR Griswold, A Bhattachar, DP Ball, JR Cross, DA Bachovchin Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation Cell Reports, 2023-01-16;0(0):111965. 2023-01-16 [PMID: 36649711] (Human)
• KI Arimoto, S Miyauchi, TD Troutman, Y Zhang, M Liu, SA Stoner, AG Davis, JB Fan, YJ Huang, M Yan, CK Glass, DE Zhang Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis Nature Communications, 2023-01-17;14(1):251. 2023-01-17 [PMID: 36646704] (Human)
• P Hennig, M Di Filippo, G Bilfeld, M Mellett, HD Beer High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells Cell Death & Disease, 2022-12-29;13(12):1077. 2022-12-29 [PMID: 36581625] (Human)
• J Park, KM Jang, KK Park Effects of Apamin on MPP+-Induced Calcium Overload and Neurotoxicity by Targeting CaMKII/ERK/p65/STAT3 Signaling Pathways in Dopaminergic Neuronal Cells International Journal of Molecular Sciences, 2022-12-03;23(23):. 2022-12-03 [PMID: 36499581] (Human)
• J Milara, F Martínez-E, P Montero, I Roger, MA Bayarri, P Ribera, MN Oishi-Kona, JR Alba-Garcí, E Zapater, J Cortijo N-acetylcysteine Reduces Inflammasome Activation Induced by SARS-CoV-2 Proteins In Vitro International Journal of Molecular Sciences, 2022-11-22;23(23):. 2022-11-22 [PMID: 36498845] (Human)
• LM Branco, MP Amaral, H Boekhoff, ABF de Lima, IS Farias, SL Lage, GJS Pereira, BS Franklin, KR Bortoluci Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1beta secretion Cell Death & Disease, 2022-12-08;13(12):1029. 2022-12-08 [PMID: 36481780] (Human)
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• MC Chiang, CJB Nicol, SS Lo, SW Hung, CJ Wang, CH Lin Resveratrol Mitigates Oxygen and Glucose Deprivation-Induced Inflammation, NLRP3 Inflammasome, and Oxidative Stress in 3D Neuronal Culture International Journal of Molecular Sciences, 2022-10-02;23(19):. 2022-10-02 [PMID: 36232980] (Human)
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• Y Wu, Y He, F Wang, N Yao, Y Zhao, Z Tian Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells Mediators of Inflammation, 2022-09-13;2022(0):9603989. 2022-09-13 [PMID: 36148140] (Human)
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• A Jin, Q Zhang, H Cheng, C Yang, X Wang Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury International immunopharmacology, 2022-04-09;108(0):108740. 2022-04-09 [PMID: 35413678] (Human)
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• YJ Kim, J Choe, SJ Moon, JW Song Blood KL-6 predicts prognosis in primary Sj�gren's syndrome-associated interstitial lung disease Scientific Reports, 2022-03-29;12(1):5343. 2022-03-29 [PMID: 35351939] (Human)
• A Kowalczuk, N Bourebaba, J Panchuk, K Marycz, L Bourebaba Calystegines Improve the Metabolic Activity of Human Adipose Derived Stromal Stem Cells (ASCs) under Hyperglycaemic Condition through the Reduction of Oxidative/ER Stress, Inflammation, and the Promotion of the AKT/PI3K/mTOR Pathway Biomolecules, 2022-03-16;12(3):. 2022-03-16 [PMID: 35327652] (Human)
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• SH Lee, MR Choi, J Chung, SH Choi, SK Park, YM Kim Povidone iodine suppresses LPS-induced inflammation by inhibiting TLR4/MyD88 formation in airway epithelial cells Scientific Reports, 2022-03-07;12(1):3681. 2022-03-07 [PMID: 35256715] (Human)
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• Y Ni, BC Hu, GH Wu, ZQ Shao, Y Zheng, R Zhang, J Jin, J Hong, XH Yang, RH Sun, JQ Liu, SJ Mo Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI Theranostics, 2021-09-13;11(19):9431-9451. 2021-09-13 [PMID: 34646379] (Mouse)
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• X Bao, Z Wang, Q Jia, S Shen, L Wu, Q Jiang, C Li, G Xu HIF-1alpha-Mediated miR-623 Regulates Apoptosis and Inflammatory Responses of Nucleus Pulposus Induced by Oxidative Stress via Targeting TXNIP Oxidative Medicine and Cellular Longevity, 2021-08-03;2021(0):6389568. 2021-08-03 [PMID: 34394829] (Human)
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• DPS Lopes, IS Ribeiro, DC Santos, FMS Lima, AA Santos, DSP Souza, DN Lopes, AO Prado, ÍS Pereira, DP Santos, GS Santos, RAA Silva Regular physical activity reduces the proinflammatory response in older women with diabetes and hypertension in the postmenopausal phase Experimental gerontology, 2021-06-11;152(0):111449. 2021-06-11 [PMID: 34126225] (Human)
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• L Avila, ML Neves, AR Abreu, CR Fiuza, L Fukusawa, N Meziat-Fil, AR Soares San Cognitive functional therapy (CFT) compared with core training exercise (CTE) in patients with failed back surgery syndrome (FBSS): A study protocol for a randomized controlled trial Journal of bodywork and movement therapies, 2020-09-14;26(0):428-434. 2020-09-14 [PMID: 33992278] (Human)
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• C Zhang, L Wang, Y Shen Circ_0004104 knockdown alleviates oxidized low-density lipoprotein-induced dysfunction in vascular endothelial cells through targeting miR-328-3p/TRIM14 axis in atherosclerosis BMC cardiovascular disorders, 2021-04-23;21(1):207. 2021-04-23 [PMID: 33892646] (Human)
• ML Vazquez-Vi, JI Gamez-Nava, AM Saldaña-Cr, A Celis, EN Sanchez-Ro, EE Perez-Guer, M Ramirez-Vi, CA Nava-Valdi, B Contreras-, JC Vasquez-Ji, JM Ponce-Guar, AK Barocio-Ra, S Cerpa-Cruz, MF Alcaraz-Lo, L Gonzalez-L Functional disability is related to serum chemerin levels in rheumatoid arthritis Scientific Reports, 2021-04-16;11(1):8360. 2021-04-16 [PMID: 33863926] (Human)
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• NE Kim, DK Kim, YJ Song SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation Microorganisms, 2021-02-26;9(3):. 2021-02-26 [PMID: 33652815] (Human)
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• CS Oh, JM Choi, EH Park, L Piao, HJ Park, KY Rhee, SH Kim Impact of Anesthetic Agents on Endothelial Glycocalyx Injury during Total Knee Arthroplasty: Desflurane- vs. Propofol-Based Anesthesia-A Prospective Randomized Controlled Trial BioMed Research International, 2021-01-23;2021(0):8880267. 2021-01-23 [PMID: 33564684] (Human)
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• YZ Akkaya-Ulu, TH Akbaba, Z Tavukcuogl, JJ Chae, E Yilmaz, S Ozen, B Balci-Peyn Familial Mediterranean fever-related miR-197-3p targets IL1R1 gene and modulates inflammation in monocytes and synovial fibroblasts Scientific Reports, 2021-01-12;11(1):685. 2021-01-12 [PMID: 33436947] (Human)
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• SA Alkandari, RG Bhardwaj, A Ellepola, M Karched Proteomics of extracellular vesicles produced by Granulicatella adiacens, which causes infective endocarditis PLoS ONE, 2020-11-20;15(11):e0227657. 2020-11-20 [PMID: 33216751] (Human)
• A Santarsier, A Onzo, R Pascale, MA Acquavia, M Coviello, P Convertini, S Todisco, M Marsico, C Pifano, P Iannece, C Gaeta, S D'Angelo, MC Padula, G Bianco, V Infantino, G Martelli Pistacia lentiscus Hydrosol: Untargeted Metabolomic Analysis and Anti-Inflammatory Activity Mediated by NF-&kappaB and the Citrate Pathway Oxid Med Cell Longev, 2020-11-01;2020(0):4264815. 2020-11-01 [PMID: 33204395] (Human)
• Y Meng, S Qiu, L Sun, J Zuo Knockdown of exosome?mediated lnc?PVT1 alleviates lipopolysaccharide?induced osteoarthritis progression by mediating the HMGB1/TLR4/NF?&kappaB pathway via miR?93?5p Molecular Medicine Reports, 2020-10-14;22(6):5313-5325. 2020-10-14 [PMID: 33174011] (Human)
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• L Peng, Y Ye, H Mullikin, L Lin, C Kuhn, M Rahmeh, S Mahner, U Jeschke, V von Schönf Expression of trophoblast derived prostaglandin E2 receptor 2 (EP2) is reduced in patients with recurrent miscarriage and EP2 regulates cell proliferation and expression of inflammatory cytokines J Reprod Immunol, 2020-10-01;142(0):103210. 2020-10-01 [PMID: 33011635] (Human)
• H Tsugawa, Y Kabe, A Kanai, Y Sugiura, S Hida, S Taniguchi, T Takahashi, H Matsui, Z Yasukawa, H Itou, K Takubo, H Suzuki, K Honda, H Handa, M Suematsu Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection PLoS Biol, 2020-09-29;18(9):e3000813. 2020-09-29 [PMID: 32991574] (Mouse)
• L Guo, Q Wang, D Zhang MicroRNA-4485 ameliorates severe influenza pneumonia via inhibition of the STAT3/PI3K/AKT signaling pathway Oncology Letters, 2020-09-09;20(5):215. 2020-09-09 [PMID: 32963621] (Human)
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FAQs for IL-1 beta/IL-1F2 (DLB50). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: IL1B