Human GITR Ligand/TNFSF18 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human GITR Ligand/TNFSF18 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TNFSF18

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human GITR Ligand/TNFSF18 DuoSet ELISA, 15 Plate

• Activation-inducible TNF-related ligand
• AITRL
• AITRLMGC138237
• GITR Ligand
• GITRL
• GITRLglucocorticoid-induced TNFR-related protein ligand
• Glucocorticoid-induced TNF-related ligand
• hGITRLGITR ligand
• TL6AITR ligand
• TNFSF18
• tumor necrosis factor (ligand) superfamily, member 18
• tumor necrosis factor ligand superfamily member 18

Background

GITR Ligand, also known as TNFSF18 and TL6, is a transmembrane glycoprotein that is expressed on antigen presenting cells, CD4-CD8- double negative thymic precursors, vascular endothelial cells, neurons, and in the eye. Its expression is transiently upregulated by proinflammatory stimulation. The binding of GITR Ligand to GITR on mouse CD25+ Treg cells permits the reactivation of T cells from Treg-induced suppression. GITR Ligand binding to GITR additionally provides a costimulatory signal to activated CD4+ and CD8+ T cells and NK cells. This interaction also induces reverse signaling in GITR Ligand expressing dendritic cells to suppress cellular activation through the same pathway induced by the immunosuppressant dexamethasone. In the brain, GITR Ligand/GITR interactions enhance NGF-mediated neurite outgrowth from sympathetic neurons.

Publications for GITR Ligand/TNFSF18 (DY694)(3)

Publications using DY694

• Liu , Yingzhao, Tang , Xinyi, Tian , Jie, Zhu , Chenlu, Peng , Huiyong, Rui , Ke, Wang , Yungang, Mao , Chaoming, Ma , Jie, Lu , Liwei, Xu , Huaxi, Wang , Shengjun Th17/Treg cells imbalance and GITRL profile in patients with Hashimoto's thyroiditis. Int J Mol Sci, 2014-11-25;15(12):21674-86. 2014-11-25 [PMID: 25429429] (Human)
• Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis. Acta Derm. Venereol., 2006-01-01;86(5):393-8. 2006-01-01 [PMID: 16955181] (Human)
• Cardona ID, Goleva E, Ou LS, Leung DY Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes. J. Allergy Clin. Immunol., 2006-01-27;117(3):688-95. 2006-01-27 [PMID: 16522472] (Human)

FAQs for GITR Ligand/TNFSF18 (DY694). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: TNFSF18