Human GDNF DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human GDNF DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: GDNF

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human GDNF DuoSet ELISA, 15 Plate

• Astrocyte-derived trophic factor
• ATF
• ATF1
• ATF2
• GDNF
• glial cell derived neurotrophic factor
• glial cell line derived neurotrophic factor
• glial cell line-derived neurotrophic factor
• HFB1-GDNF
• HGDNF
• HSCR3

Background

GDNF (Glial Cell Line-derived Neurotrophic Factor) is a secreted protein that promotes the survival of motoneurons, midbrain dopaminergic neurons, Purkinje cells, and sympathetic neurons. It is produced by Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes, and skeletal muscle cells. GDNF binding to GFR alpha 1 induces the recruitment of Ret, NCAM-1/CD56, various integrins, Syndecan-3, or N-Cadherin. GDNF-based therapies show promise in several neurodegenerative disorders, particularly Parkinson’s disease.

Publications for GDNF (DY212)(40)

Publications using DY212

• Ribeiro, R;Silva, EG;Moreira, FC;Gomes, GF;Cussat, GR;Silva, BSR;da Silva, MCM;de Barros Fernandes, H;de Sena Oliveira, C;de Oliveira Guarnieri, L;Lopes, V;Ferreira, CN;de Faria, AMC;Maioli, TU;Ribeiro, FM;de Miranda, AS;Moraes, GSP;de Oliveira, ACP;Vieira, LB; Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling Scientific reports 2023-09-29 [PMID: 37773430] (Mouse)
• Marcelo Duarte Azevedo, Naika Prince, Marie Humbert-Claude, Virginia Mesa-Infante, Cheryl Jeanneret, Valentine Golzne et al. Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation Mol Ther Methods Clin Dev 2023-12-14 [PMID: 37766790] (Rat)
• Ford, MM;George, BE;Van Laar, VS;Holleran, KM;Naidoo, J;Hadaczek, P;Vanderhooft, LE;Peck, EG;Dawes, MH;Ohno, K;Bringas, J;McBride, JL;Samaranch, L;Forsayeth, JR;Jones, SR;Grant, KA;Bankiewicz, KS; GDNF gene therapy for alcohol use disorder in male non-human primates Nature medicine 2023-08-01 [PMID: 37580533] (Primate - Rhesus macaque)
• EV Novosadova, OV Dolotov, LV Novosadova, LI Davydova, KV Sidoruk, EL Arsenyeva, DM Shimchenko, VG Debabov, VG Bogush, VZ Tarantul Composite Coatings Based on Recombinant Spidroins and Peptides with Motifs of the Extracellular Matrix Proteins Enhance Neuronal Differentiation of Neural Precursor Cells Derived from Human Induced Pluripotent Stem Cells International Journal of Molecular Sciences, 2023-03-02;24(5):. 2023-03-02 [PMID: 36902300] (Human)
• A Escobar, MR Carvalho, FR Maia, RL Reis, TH Silva, JM Oliveira Glial Cell Line-Derived Neurotrophic Factor-Loaded CMCht/PAMAM Dendrimer Nanoparticles for Peripheral Nerve Repair Pharmaceutics, 2022-11-08;14(11):. 2022-11-08 [PMID: 36365226] (Human)
• RH Baloh, JP Johnson, P Avalos, P Allred, S Svendsen, G Gowing, K Roxas, A Wu, B Donahue, S Osborne, G Lawless, B Shelley, K Wheeler, C Prina, D Fine, T Kendra-Rom, H Stokes, V Manoukian, A Muthukumar, L Garcia, MG Bañuelos, M Godoy, C Bresee, H Yu, D Drazin, L Ross, R Naruse, H Babu, EA Macklin, A Vo, A Elsayegh, W Tourtellot, M Maya, M Burford, F Diaz, CG Patil, RA Lewis, CN Svendsen Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial Nature Medicine, 2022-09-05;28(9):1813-1822. 2022-09-05 [PMID: 36064599] (Rat)
• P Szpakowski, D Ksiazek-Wi, M Turniak-Ku, I Pacan, A Glabinski Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli Biomedicines, 2022-07-22;10(8):. 2022-07-22 [PMID: 35892669] (Human)
• B Khaleel, E Lunenfeld, J Kapelushni, M Huleihel Effect of Chemotherapy Cytarabine and Acute Myeloid Leukemia on the Development of Spermatogenesis at the Adult Age of Immature Treated Mice International Journal of Molecular Sciences, 2022-04-04;23(7):. 2022-04-04 [PMID: 35409373] (Human)
• R Islamov, F Bashirov, A Izmailov, F Fadeev, V Markosyan, M Sokolov, M Shmarov, D Logunov, B Naroditsky, I Lavrov New Therapy for Spinal Cord Injury: Autologous Genetically-Enriched Leucoconcentrate Integrated with Epidural Electrical Stimulation Cells, 2022-01-02;11(1):. 2022-01-02 [PMID: 35011706] (Human)
• HL Lee, CE Yeum, H Lee, J Oh, JT Kim, WJ Lee, Y Ha, YI Yang, KN Kim Peripheral Nerve-Derived Stem Cell Spheroids Induce Functional Recovery and Repair after Spinal Cord Injury in Rodents International Journal of Molecular Sciences, 2021-04-16;22(8):. 2021-04-16 [PMID: 33923671] (Human)
• R von Känel, M Hamer, A Wentzel, L Malan Circulating neurotrophins and hemostatic risk factors of atherothrombotic cardiovascular disease at baseline and during sympathetic challenge: the SABPA study Scientific Reports, 2021-01-27;11(1):2297. 2021-01-27 [PMID: 33504912] (Human)
• M Chenlo, IA Rodriguez-, R Serramito, AR Garcia-Ren, R Villar-Tai, E Fernandez-, S Perez-Rome, M Suarez-Far, A Garcia-All, JM Cabezas-Ag, J Rodriguez-, PV Lear, RM Alvarez-Sa, C Alvarez-Es, I Bernabeu, CV Alvarez Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly EBioMedicine, 2019-04-08;0(0):. 2019-04-08 [PMID: 30975543] (Human)
• G Paolone, C Falcicchia, F Lovisari, M Kokaia, WJ Bell, T Fradet, M Barbieri, LU Wahlberg, DF Emerich, M Simonato Long-term, targeted delivery of GDNF from encapsulated cells is neuroprotective and reduces seizures in the pilocarpine model of epilepsy J. Neurosci., 2019-01-21;0(0):. 2019-01-21 [PMID: 30665947] (Human)
• CS Chu, CL Chu, CC Wu, T Lu Serum nerve growth factor beta, brain- and glial-derived neurotrophic factor levels and psychopathology in unmedicated patients with schizophrenia J Chin Med Assoc, 2018-02-01;0(0):. 2018-02-01 [PMID: 29366645] (Human)
• Y Gothelf, H Kaspi, N Abramov, R Aricha miRNA profiling of NurOwn�: mesenchymal stem cells secreting neurotrophic factors Stem Cell Res Ther, 2017-11-07;8(1):249. 2017-11-07 [PMID: 29116031] (Human)
• MA Stefani, R Modkovski, G Hansel, ER Zimmer, A Kopczynski, AP Muller, NR Strogulski, MS Rodolphi, RK Carteri, AP Schmidt, JP Oses, DH Smith, LV Portela Elevated glutamate and lactate predict brain death after severe head trauma Ann Clin Transl Neurol, 2017-05-04;4(6):392-402. 2017-05-04 [PMID: 28589166] (Human)
• P Baranov, H Lin, K McCabe, D Gale, S Cai, B Lieppman, D Morrow, P Lei, J Liao, M Young A Novel Neuroprotective Small Molecule for Glial Cell Derived Neurotrophic Factor Induction and Photoreceptor Rescue J Ocul Pharmacol Ther, 2017-04-25;0(0):. 2017-04-25 [PMID: 28441076] (Human, Mouse)
• Z Li, X Li, MTV Chan, WKK Wu, D Tan, J Shen Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation J. Cell. Mol. Med., 2017-04-21;0(0):. 2017-04-21 [PMID: 28429571] (Rat)
• GM Thomsen, M Alkaslasi, JP Vit, G Lawless, M Godoy, G Gowing, O Shelest, CN Svendsen Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1(G93A) ALS rat but has adverse side effects Gene Ther, 2017-03-09;0(0):. 2017-03-09 [PMID: 28276446] (Rat)
• Cynthia Azeredo Cordeiro Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis Braz J Infect Dis, 2016-12-05;0(0):. 2016-12-05 [PMID: 27932287] (Human)
• Lie Zhu NG2 expression in microglial cells affects the expression of neurotrophic and proinflammatory factors by regulating FAK phosphorylation Sci Rep, 2016-06-16;6(0):27983. 2016-06-16 [PMID: 27306838] (Mouse, Rat)
• Yurek D, Hasselrot U, Cass W, Sesenoglu-Laird O, Padegimas L, Cooper M Age and lesion-induced increases of GDNF transgene expression in brain following intracerebral injections of DNA nanoparticles. Neuroscience, 2014-10-22;284(0):500-12. 2014-10-22 [PMID: 25453772] (Human)
• Kim , Kwang S, Lee , Hong J, An , Jin, Kim , Yun B, Ra , Jung Cha, Lim , Inja, Kim , Seung U Transplantation of human adipose tissue-derived stem cells delays clinical onset and prolongs life span in ALS mouse model. Cell Transplant, 2013-09-18;23(12):1585-97. 2013-09-18 [PMID: 24070071] (Human)
• Zhang L, Li K, Liu X, Li D, Luo C, Fu B, Cui S, Zhu F, Zhao R, Chen X Repeated systemic administration of human adipose-derived stem cells attenuates overt diabetic nephropathy in rats. Stem Cells Dev, 2013-08-21;22(23):3074-86. 2013-08-21 [PMID: 23844841] (Human)
• Ohshima-Hosoyama S, Simmons HA, Goecks N A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys. PLoS ONE, 2012-06-20;7(6):e39036. 2012-06-20 [PMID: 22745701] (Primate - Macaca mulatta (Rhesus Macaque))
• Non-viral gene therapy for GDNF production in RCS rat: the crucial role of the plasmid dose. Gene Ther., 2011-10-13;19(9):886-98. 2011-10-13 [PMID: 21993171] (Rat)
• Jones JL, Anderson JM, Phuah CL, Fox EJ, Selmaj K, Margolin D, Lake SL, Palmer J, Thompson SJ, Wilkins A, Webber DJ, Compston DA, Coles AJ Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain, 2010-07-21;133(0):2232-47. 2010-07-21 [PMID: 20659956] (Human)
• Glavaski-Joksimovic A, Virag T, Mangatu TA Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease. J. Neurosci. Res., 2010-09-01;88(12):2669-81. 2010-09-01 [PMID: 20544825] (Human)
• Han Y, Chang QA, Virag T Lack of humoral immune response to the tetracycline (Tet) activator in rats injected intracranially with Tet-off rAAV vectors. Gene Ther., 2010-02-18;17(5):616-25. 2010-02-18 [PMID: 20164859] (Rat)
• Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology, 2010-02-11;58(7):1114-21. 2010-02-11 [PMID: 20153340] (Rat)
• Emborg ME, Moirano J, Raschke J, Bondarenko V, Zufferey R, Peng S, Ebert AD, Joers V, Roitberg B, Holden JE, Koprich J, Lipton J, Kordower JH, Aebischer P Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF. Neurobiol. Dis., 2009-08-04;36(2):303-11. 2009-08-04 [PMID: 19660547] (Primate - Macaca mulatta (Rhesus Macaque))
• Mertens B, Massie A, Michotte Y, Sarre S Effect of nigrostriatal damage induced by 6-hydroxydopamine on the expression of glial cell line-derived neurotrophic factor in the striatum of the rat. Neuroscience, 2009-04-19;162(1):148-54. 2009-04-19 [PMID: 19383530] (Rat)
• Suzuki M, McHugh J, Tork C, Shelley B, Hayes A, Bellantuono I, Aebischer P, Svendsen CN Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Mol. Ther., 2008-09-16;16(12):2002-10. 2008-09-16 [PMID: 18797452] (Human)
• Wang YC, Wu YT, Huang HY, Lin HI, Lo LW, Tzeng SF, Yang CS Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury. Biomaterials, 2008-09-06;29(34):4546-53. 2008-09-06 [PMID: 18774604] (Human)
• Sajadi A, Bensadoun JC, Schneider BL, Lo Bianco C, Aebischer P Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease. Neurobiol. Dis., 2005-11-21;22(1):119-29. 2005-11-21 [PMID: 16300956] (Human)
• Caggiula M, Batocchi AP, Frisullo G, Angelucci F, Patanella AK, Sancricca C, Nociti V, Tonali PA, Mirabella M Neurotrophic factors in relapsing remitting and secondary progressive multiple sclerosis patients during interferon beta therapy. Clin. Immunol., 2005-11-07;118(1):77-82. 2005-11-07 [PMID: 16275091] (Human)
• Puskovic V, Wolfe D, Goss J, Huang S, Mata M, Glorioso JC, Fink DJ Prolonged biologically active transgene expression driven by HSV LAP2 in brain in vivo. Mol. Ther., 2004-07-01;10(1):67-75. 2004-07-01 [PMID: 15233943] (Rat)
• Yu G, Xu L, Hadman M, Hess DC, Borlongan CV Intracerebral transplantation of carotid body in rats with transient middle cerebral artery occlusion. Brain Res., 2004-07-23;1015(1):50-6. 2004-07-23 [PMID: 15223366] (Rat)
• Truckenmiller ME, Vawter MP, Zhang P, Conejero-Goldberg C, Dillon-Carter O, Morales N, Cheadle C, Becker KG, Freed WJ AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expression. Exp. Neurol., 2002-06-01;175(0):318. 2002-06-01 [PMID: 12061863] (Rat)
• Bensadoun JC, Deglon N, Tseng JL, Ridet JL, Zurn AD, Aebischer P Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF. Exp. Neurol., 2000-07-01;164(1):15-24. 2000-07-01 [PMID: 10877911] (Human)

FAQs for GDNF (DY212). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: GDNF