Human FGF acidic/FGF1 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human FGF acidic/FGF1 Quantikine ELISA Kit Summary

• Background: The Quantikine Human FGF acidic Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human FGF acidic in cell culture supernates, serum, plasma, and urine. It contains E. coli-expressed recombinant human FGF acidic and has been shown to accurately quantitate the recombinant factor.
• Specificity: Natural and recombinant human FGF acidic
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: FGF1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human FGF acidic/FGF1 Quantikine ELISA Kit

• AFGF
• alpha
• alpha-ECGF
• beta-ECGF
• ECGF
• ECGFB
• ECGF-betaAcidic fibroblast growth factor
• endothelial cell growth factor, beta
• FGF acidic
• FGF-1
• FGFABeta-endothelial cell growth factor
• FGF-alpha
• fibroblast growth factor 1 (acidic)
• GLIO703
• HBGF1
• HBGF-1
• heparin-binding growth factor 1

Background

FGF acidic, also known as FGF-1, ECGF, and HBGF-1, is a secreted mitogen that stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. FGF acidic is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF acidic with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Internalized FGF acidic can translocate to the cytosol and to the nucleus. Intracellular FGF acidic functions as a survival factor by inhibiting p53 activity and proapoptotic signaling.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for FGF acidic/FGF1 (DFA00B)(10)

Publications using DFA00B

• C Eggermont, P Giron, M Noeparast, H Vandenplas, P Aza-Blanc, GJ Gutierrez, J De Grève The EGFR-STYK1-FGF1 axis sustains functional drug tolerance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer Oncogene, 2022-07-15;13(7):611. 2022-07-15 [PMID: 35840561] (Human)
• Q Hui, R Yang, C Lu, J Bi, L Li, J Gong, L Zhang, Z Jin, X Li, X Wang Validation of a Double-Sandwich Enzyme-Linked Immunoassay for Pharmacokinetic Study of an rh-aFGF Hydrogel in Rat Skin and Serum Front Pharmacol, 2020-05-19;11(0):700. 2020-05-19 [PMID: 32508643] (Human)
• Sohinee Bhattacharyya, Chet Oon, Aayush Kothari, Wesley Horton, Jason Link, Rosalie C. Sears et al. Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer Journal of Experimental Medicine 2020-08-03 [PMID: 32434218] (Human)
• EK Day, NG Sosale, A Xiao, Q Zhong, B Purow, MJ Lazzara Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling Cell Rep, 2020-03-10;30(10):3383-3396.e7. 2020-03-10 [PMID: 32160544] (Human)
• Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer. Br. J. Cancer, 2012-09-18;107(8):1327-36. 2012-09-18 [PMID: 22990650] (Human)
• Sherman JA, Hall A, Malenka DJ, De Muinck ED, Simons M Humoral and cellular factors responsible for coronary collateral formation. Am. J. Cardiol., 2006-08-31;98(9):1194-7. 2006-08-31 [PMID: 17056326] (Human)
• Beck LA, Tancowny B, Brummet ME, Asaki SY, Curry SL, Penno MB, Foster M, Bahl A, Stellato C Functional analysis of the chemokine receptor CCR3 on airway epithelial cells. J. Immunol., 2006-09-01;177(5):3344-54. 2006-09-01 [PMID: 16920975] (Human)
• Herrmann S, Green J, Weber T, Scharfenberger A Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone, 2006-07-25;39(5):1156-63. 2006-07-25 [PMID: 16863704] (Human)
• Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J. Immunol., 2005-11-01;175(9):6177-89. 2005-11-01 [PMID: 16237115] (Human)
• Stapelberg M, Gellert N, Swettenham E, Tomasetti M, Witting PK, Procopio A, Neuzil J Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. J. Biol. Chem., 2005-05-05;280(27):25369-76. 2005-05-05 [PMID: 15878867] (Human)

Bioinformatics

• Gene Symbol: FGF1