Human EMMPRIN/CD147 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human EMMPRIN/CD147 Quantikine ELISA Kit Summary

• Background: The Quantikine Human EMMPRIN Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human EMMPRIN in cell culture supernates, serum, plasma, saliva, urine, and human milk. It contains NS0-expressed recombinant human EMMPRIN and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human EMMPRIN showed linear curves that were parallel to the s...tandard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally ocurring EMMPRIN.
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• Specificity: Natural and recombinant human EMMPRIN
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: BSG

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human EMMPRIN/CD147 Quantikine ELISA Kit

• 5F7
• basigin (Ok blood group)
• Basigin
• BSG
• CD147 antigen
• CD147
• Collagenase stimulatory factor
• EMMPRIN
• EMMPRINTCSF
• Extracellular matrix metalloproteinase inducer
• Leukocyte activation antigen M6
• M6
• OK blood group antigen
• OK
• Tumor cell-derived collagenase stimulatory factor

Background

The name EMMPRIN reflects this proteins extracellular metalloproteinase inducer activity. It is a cell surface protein with two extracellular Ig domains, a transmembrane domain, and a cytoplasmic domain. Its expression is often elevated in human tumor cells, which in turn promotes MMP-1, MMP-2 and MMP-3 production in melanoma cells and MMP-2 and MMP-9 production in breast cancer cells. It interacts with several types of molecules such as integrins, caveolin-1 and MCT1. TRA-1-85 is an epitope within EMMPRIN.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for EMMPRIN/CD147 (DEMP00)(8)

Publications using DEMP00

• LY Wang, CS Tan, MKP Lai, S Hilal Factors Associated with RANTES, EMMPIRIN, MMP2 and MMP9, and the Association of These Biomarkers with Cardiovascular Disease in a Multi-Ethnic Population Journal of Clinical Medicine, 2022-12-08;11(24):. 2022-12-08 [PMID: 36555898] (Human)
• GJ Wang, X Dong, Y Li Cluster of Differentiation 147 (CD147) serves as a promoter of atherosclerosis in patients with cerebral infarction European review for medical and pharmacological sciences, 2022-08-01;26(16):5710-5717. 2022-08-01 [PMID: 36066144] (Human)
• P ?acina, A Butrym, E Turlej, M Stachowicz, J Wietrzyk, G Mazur, K Bogunia-Ku BSG (CD147) Serum Level and Genetic Variants Are Associated with Overall Survival in Acute Myeloid Leukaemia Journal of Clinical Medicine, 2022-01-10;11(2):. 2022-01-10 [PMID: 35054026] (Human)
• MM Ali, I Mirza, D Naquiallah, C Hassan, M Masrur, FM Bianco, AM Mahmoud CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults Journal of cardiovascular development and disease, 2021-12-28;9(1):. 2021-12-28 [PMID: 35050217] (Human)
• H Wang, J Ye, R Liu, G Chen, J Zhao, L Huang, F Yang, M Li, S Zhang, Jingxie, L Xiong, H Chen, Y Xu, M Su, Y Xie, S Li, F Zheng, L Geng, W Xu, S Gong Clinical Significance of CD147 in Children with Inflammatory Bowel Disease Biomed Res Int, 2020-09-15;2020(0):7647181. 2020-09-15 [PMID: 33015178] (Human)
• E Rurali, GL Perrucci, R Gaetano, A Pini, D Moschetta, D Gentilini, P Nigro, G Pompilio Soluble EMMPRIN levels discriminate aortic ectasia in Marfan syndrome patients Theranostics, 2019-04-12;9(8):2224-2234. 2019-04-12 [PMID: 31149040] (Human)
• BL Updegraff, X Zhou, Y Guo, MS Padanad, PH Chen, C Yang, J Sudderth, C Rodriguez-, L Girard, JD Minna, P Mishra, RJ DeBerardin, KA O'Donnell Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism Cell Rep, 2018-11-20;25(8):2223-2233.e6. 2018-11-20 [PMID: 30463017] (Human)
• Wu J, Hao Z, Zhao Y, Yang X, Tang H, Zhang X, Song F, Sun X, Wang B, Nan G, Chen Z, Bian H Full-length soluble CD147 promotes MMP-2 expression and is a potential serological marker in detection of hepatocellular carcinoma. J Transl Med, 2014-07-04;12(0):190. 2014-07-04 [PMID: 24996644] (Human)

FAQs for EMMPRIN/CD147 (DEMP00). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: BSG