Human EDIL3 DuoSet ELISA, 5 Plate

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Human EDIL3 DuoSet ELISA, 5 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
EDIL3

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY6046-05.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human EDIL3 DuoSet ELISA, 5 Plate

  • DEL1
  • DEL1developmental endothelial locus-1
  • Developmentally-regulated endothelial cell locus 1 protein
  • EDIL3
  • EGF-like repeat and discoidin I-like domain-containing protein 3
  • EGF-like repeats and discoidin I-like domains 3
  • Integrin-binding protein DEL1
  • MGC26287

Background

EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3; also Del-1 and integrin-binding DEL1) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. Human EDIL3 is synthesized as a precursor with a 16 amino acid (aa) signal sequence and a 464 aa mature chain (SwissProt # O43854). The mature chain is composed of three epidermal growth factor (EGF) repeats and two discoidin-I-like domains. The second EGF repeat contains an RGD motif. Splicing variants produce two isoforms for human EDIL3. Isoform 2 has an A -> G substitution at aa 66 and a deletion of aa 67-76 found in isoform 1. Mature human EDIL3 shares 96% aa sequence identity with mature mouse EDIL3. The RGD motif of EDIL3 binds alpha v beta 5 integrin, which, in turn, leads to increased angiogenic transcription factor HoxD3 expression. HoxD3 activates alpha v beta 3 and uPA, resulting in the transformation of resting endothelial cells to an angiogenic state. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. It has been found, however, re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence and migration of endothelial cells, and acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. Exogenous application of EDIL3 has been demonstrated to augment angiogenesis and improve blood flow and tissue function in murine models of hind-limb ischemia, cardiac ischemia and cerebral ischemia. EDIL3 has also been shown to be an endogenous inhibitor of inflammatory cell recruitment by interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion.

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DY6046-05
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Applications: ELISA

Publications for EDIL3/DEL1 (DY6046-05)(4)

We have publications tested in 1 confirmed species: Human.


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Human
(4)
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Showing Publications 1 - 4 of 4.
Publications using DY6046-05 Applications Species
DH Joo, KH Lee, CH Lee, J Woo, J Kim, SJ Park, CK Rhee, WY Lee, D Park, JS Lee, KS Jung, KH Yoo, CG Yoo Developmental endothelial locus-1 as a potential biomarker for the incidence of acute exacerbation in patients with chronic obstructive pulmonary disease Respiratory Research, 2021;22(1):297. 2021 [PMID: 34801026] (Human) Human
SJ Lee, JH Jeong, SH Kang, J Kang, EA Kim, J Lee, JH Jung, HY Park, YS Chae MicroRNA-137 Inhibits Cancer Progression by Targeting Del-1 in Triple-Negative Breast Cancer Cells Int J Mol Sci, 2019;20(24):. 2019 [PMID: 31817673] (Human) Human
I Kourtzelis, X Li, I Mitroulis, D Grosser, T Kajikawa, B Wang, M Grzybek, J von Reness, A Czogalla, M Troullinak, A Ferreira, C Doreth, K Ruppova, LS Chen, K Hosur, JH Lim, KJ Chung, S Grossklaus, AK Tausche, LAB Joosten, NM Moutsopoul, B Wielockx, A Castrillo, JM Korostoff, Ü Coskun, G Hajishenga, T Chavakis DEL-1 promotes macrophage efferocytosis and clearance of inflammation Nat. Immunol., 2018;0(0):. 2018 [PMID: 30455459] (Human) Human
I Mitroulis, LS Chen, RP Singh, I Kourtzelis, M Economopou, T Kajikawa, M Troullinak, A Ziogas, K Ruppova, K Hosur, T Maekawa, B Wang, P Subramania, T Tonn, P Verginis, M von Bonin, M Wobus, M Bornhäuser, T Grinenko, M Di Scala, A Hidalgo, B Wielockx, G Hajishenga, T Chavakis Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche J. Clin. Invest., 2017;0(0):. 2017 [PMID: 28846069] (Human) Human

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Bioinformatics

Gene Symbol EDIL3