Human Decorin DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Decorin DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: DCN

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Decorin DuoSet ELISA, 15 Plate

• Bone proteoglycan II
• CSCD
• DCN
• decorin proteoglycan
• Decorin
• dermatan sulphate proteoglycans II
• DSPG2
• PG40
• PGII
• PG-II
• PGS2
• PG-S2
• proteoglycan core protein
• SLRR1B
• SLRR1BPGS2
• small leucine-rich protein 1B

Background

Decorin, also known as PG40 and PGS2, is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors basic FGF, GDF-8/Myostatin, TGF-beta, and WISP-1. It also binds and activates EGF R, ErbB4, and IGF-I R. Decorin promotes myoblast differentiation, supports angiogenesis, and inhibits tumor progression.

Publications for Decorin (DY143)(19)

Publications using DY143

• de Fontes-Junior, AA;de Sousa, CAZ;de Oliveira, LB;Sierra, APR;Cury-Boaventura, MF; Decorin levels and cardiometabolic function after endurance exercise Frontiers in physiology 2025-07-08 [PMID: 40697980] (Human)
• Moqaddam, MA;Nemati, M;Dara, MM;Hoteit, M;Sadek, Z;Ramezani, A;Rand, MK;Abbassi-Daloii, A;Pashaei, Z;Almaqhawi, A;Razi, O;Escobar, KA;Supriya, R;Saeidi, A;Zouhal, H; Exploring the Impact of Astaxanthin Supplementation in Conjunction with a 12-Week CrossFit Training Regimen on Selected Adipo-Myokines Levels in Obese Males Nutrients 2024-08-26 [PMID: 39275173] (Human)
• KEC Blokland, M Nizamoglu, H Habibie, T Borghuis, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts Frontiers in Pharmacology, 2022-11-03;13(0):989169. 2022-11-03 [PMID: 36408252] (Human)
• J Liu, S Zhu, L Zeng, J Li, DJ Klionsky, G Kroemer, J Jiang, D Tang, R Kang DCN released from ferroptotic cells ignites AGER-dependent immune responses Autophagy, 2021-12-29;0(0):1-14. 2021-12-29 [PMID: 34964698] (Human)
• K Micielska, M Flis, JA Kortas, E Rodziewicz, J Antosiewic, K Wochna, G Lombardi, E Ziemann Nordic Walking Rather Than High Intensity Interval Training Reduced Myostatin Concentration More Effectively in Elderly Subjects and the Range of This Drop Was Modified by Metabolites of Vitamin D Nutrients, 2021-12-08;13(12):. 2021-12-08 [PMID: 34959945] (Human)
• KEC Blokland, H Habibie, T Borghuis, GJ Teitsma, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM Cells, 2021-06-29;10(7):. 2021-06-29 [PMID: 34209854] (Human)
• T Pemmari, L Ivanova, U May, P Lingasamy, A Tobi, A Pasternack, S Prince, O Ritvos, S Makkapati, T Teesalu, MS Cairo, TAH Järvinen, Y Liao Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa Mol. Ther., 2020-05-20;0(0):. 2020-05-20 [PMID: 32497513] (Mouse)
• J Kortas, E Ziemann, D Juszczak, K Micielska, M Koz?owska, K Prusik, K Prusik, J Antosiewic Iron Status in Elderly Women Impacts Myostatin, Adiponectin and Osteocalcin Levels Induced by Nordic Walking Training Nutrients, 2020-04-17;12(4):. 2020-04-17 [PMID: 32316589] (Human)
• N Jiang, Q Zhang, MK Chau, MS Yip, SL Lui, S Liu, KM Chu, HY Ngan, TM Chan, S Yung Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis EBioMedicine, 2020-02-12;52(0):102661. 2020-02-12 [PMID: 32062358] (Human)
• G Begum, J O'Neill, R Chaudhary, K Blachford, DRJ Snead, M Berry, RAH Scott, A Logan, RJ Blanch Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study Invest. Ophthalmol. Vis. Sci., 2018-10-01;59(12):4929-4936. 2018-10-01 [PMID: 30347087] (Human)
• Y Yang, QH Wu, Y Li, PJ Gao Association of SLRPs with carotid artery atherosclerosis in essential hypertensive patients J Hum Hypertens, 2018-06-05;0(0):. 2018-06-05 [PMID: 29867136] (Human)
• S Hinderer, K Sudrow, M Schneider, M Holeiter, SL Layland, M Seifert, K Schenke-La Surface functionalization of electrospun scaffolds using recombinant human decorin attracts circulating endothelial progenitor cells Sci Rep, 2018-01-08;8(1):110. 2018-01-08 [PMID: 29311692] (Chinese Hamster)
• Huang S, Lin H, Yao M, Tang J, Wu S, Hou H, Chou W, Chou S, Hsu S, Ko B, Lu H, Tsay W, Tien H Higher Decorin Levels in Bone Marrow Plasma Are Associated with Superior Treatment Response to Novel Agent-Based Induction in Patients with Newly Diagnosed Myeloma - A Retrospective Study. PLoS ONE, 2015-09-17;10(9):e0137552. 2015-09-17 [PMID: 26379028] (Human)
• Kwan P, Ding J, Tredget E MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. PLoS ONE, 2015-04-02;10(4):e0123054. 2015-04-02 [PMID: 25837671] (Human)
• Nemani N, Santo L, Eda H, Cirstea D, Mishima Y, Patel C, O'Donnell E, Yee A, Raje N Role of decorin in multiple myeloma (MM) bone marrow microenvironment. J Bone Miner Res, 2015-03-01;30(3):465-70. 2015-03-01 [PMID: 25407518] (Human)
• Kristensen I, Christensen J, Lyng M, Moller M, Pedersen L, Rasmussen L, Ditzel H, Abildgaard N Hepatocyte growth factor pathway upregulation in the bone marrow microenvironment in multiple myeloma is associated with lytic bone disease. Br J Haematol, 2013-02-22;161(3):373-82. 2013-02-22 [PMID: 23431957] (Human)
• Onuma , Hiroshi, Tabara , Yasuharu, Kawamura , Ryoichi, Ohashi , Jun, Nishida , Wataru, Takata , Yasunori, Ochi , Masaaki, Nishimiya , Tatsuya, Kawamoto , Ryuichi, Kohara , Katsuhik, Miki , Tetsuro, Osawa , Haruhiko Plasma resistin is associated with single nucleotide polymorphisms of a possible resistin receptor, the decorin gene, in the general Japanese population. Diabetes, 2012-11-27;62(2):649-52. 2012-11-27 [PMID: 23193185] (Human)
• Paul E. Matuszewski, Yi-Ling Chen, Spencer E. Szczesny, Spencer P. Lake, Dawn M. Elliott, Louis J. Soslowsky et al. Regional Variation in Human Supraspinatus Tendon Proteoglycans: Decorin, Biglycan, and Aggrecan Connective Tissue Research 2012-10-01 [PMID: 22329809] (Human)
• Wu IC, Wu DC, Huang CC Plasma decorin predicts the presence of esophageal squamous cell carcinoma. Int. J. Cancer, 2010-11-01;127(9):2138-46. 2010-11-01 [PMID: 20143390] (Human)

FAQs for Decorin (DY143). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: DCN