Human CCL22/MDC DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human CCL22/MDC DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CCL22

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CCL22/MDC DuoSet ELISA, 15 Plate

• A-152E5.1
• ABCD-1
• CC chemokine STCP-1
• C-C motif chemokine 22
• CCL22
• chemokine (C-C motif) ligand 22
• DC/B-CK
• Macrophage-derived chemokine
• MDC
• MDCStimulated T-cell chemotactic protein 1
• MGC34554
• SCYA22MDC(1-69)
• small inducible cytokine A22
• small inducible cytokine subfamily A (Cys-Cys), member 22
• Small-inducible cytokine A22
• STCP-1
• stimulated T cell chemotactic protein 1

Background

Macrophage-derived chemokine (MDC), also named stimulated T cell chemotactic protein (STCP-1) and ABCD-1, and now designated as CCL22, is a CC chemokine initially isolated from clones of monocyte-derived macrophages. At the amino acid sequence level, MDC shows less than 35% identity to other CC chemokine family members. Human MDC is expressed in dendritic cells, macrophages and activated monocytes. In addition, MDC expression is detected in thymus, lymph node and appendix tissues. At the amino acid sequence level, mouse and human MDC share 64% identity and 83% similarity.

Publications for CCL22/MDC (DY336)(25)

Publications using DY336

• Seo, DY;Park, JW;Kim, SH;Oh, SR;Han, SB;Kwon, OK;Ahn, KS; Effect of Isoscopoletin on Cytokine Expression in HaCaT Keratinocytes and RBL-2H3 Basophils: Preliminary Study International journal of molecular sciences 2024-06-24 [PMID: 39000019] (Human)
• Katsoulis, O;Toussaint, M;Jackson, MM;Mallia, P;Footitt, J;Mincham, KT;Meyer, GFM;Kebadze, T;Gilmour, A;Long, M;Aswani, AD;Snelgrove, RJ;Johnston, SL;Chalmers, JD;Singanayagam, A; Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations Nature communications 2024-07-09 [PMID: 38982052] (Human)
• Brollo, M;Salvator, H;Grassin-Delyle, S;Glorion, M;Descamps, D;Buenestado, A;Naline, E;Tenor, H;Tiotiu, A;Devillier, P; The IL-4/13-induced production of M2 chemokines by human lung macrophages is enhanced by adenosine and PGE2 International immunopharmacology 2024-01-23 [PMID: 38266451] (Human)
• H Janbazacya, J van Bergen, S Varasteh, J Garssen, G Folkerts, S Braber Repeated exposure of bronchial epithelial cells to particular matter increases allergen-induced cytokine release and permeability Cytokine, 2022-04-08;154(0):155878. 2022-04-08 [PMID: 35405483] (Human)
• ML Tsai, YG Tsai, YC Lin, YL Hsu, YT Chen, MK Tsai, WT Liao, YC Lin, CH Hung IL-25 Induced ROS-Mediated M2 Macrophage Polarization via AMPK-Associated Mitophagy International Journal of Molecular Sciences, 2021-12-21;23(1):. 2021-12-21 [PMID: 35008429] (Human)
• H Lee, DH Lee, JH Oh, JH Chung Skullcapflavone II Suppresses TNF-alpha/IFN-gamma-Induced TARC, MDC, and CTSS Production in HaCaT Cells International Journal of Molecular Sciences, 2021-06-16;22(12):. 2021-06-16 [PMID: 34208434] (Human)
• ZS Wong, SL Sokol-Borr, P Olias, JP Dubey, JP Boyle Head-to-head comparisons of Toxoplasma gondii and its near relative Hammondia hammondi reveal dramatic differences in the host response and effectors with species-specific functions PLoS Pathog., 2020-06-23;16(6):e1008528. 2020-06-23 [PMID: 32574210] (Human)
• SS Foo, W Chen, Y Chan, WS Lee, SA Lee, G Cheng, K Nielsen-Sa, P Brasil, JU Jung Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies JCI Insight, 2018-11-02;3(21):. 2018-11-02 [PMID: 30385728] (Human)
• JW Park, HS Lee, Y Lim, JH Paik, OK Kwon, JH Kim, I Paryanto, P Yunianto, S Choi, SR Oh, KS Ahn Rhododendron album Blume extract inhibits TNF-?/IFN-?-induced chemokine production via blockade of NF-?B and JAK/STAT activation in human epidermal keratinocytes Int. J. Mol. Med., 2018-03-09;0(0):. 2018-03-09 [PMID: 29532855] (Human)
• SE Ander, EN Rudzki, N Arora, Y Sadovsky, CB Coyne, JP Boyle Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines MBio, 2018-01-09;9(1):. 2018-01-09 [PMID: 29317509] (Human)
• Evelina Martinenai CCL22-specific T Cells: Modulating the immunosuppressive tumor microenvironment Oncoimmunology, 2016-09-30;5(11):e1238541. 2016-09-30 [PMID: 27999757] (Human)
• Forsythia suspensa Suppresses House Dust Mite Extract-Induced Atopic Dermatitis in NC/Nga Mice PLoS ONE, 2016-12-09;11(12):e0167687. 2016-12-09 [PMID: 27936051] (Human)
• Puig K, Manocha G, Combs C Amyloid precursor protein mediated changes in intestinal epithelial phenotype in vitro. PLoS ONE, 2015-03-05;10(3):e0119534. 2015-03-05 [PMID: 25742317] (Human)
• Jaguin M, Fardel O, Lecureur V Exposure to diesel exhaust particle extracts (DEPe) impairs some polarization markers and functions of human macrophages through activation of AhR and Nrf2. PLoS ONE, 2015-02-24;10(2):e0116560. 2015-02-24 [PMID: 25710172] (Human)
• Schupp J, Binder H, Jager B, Cillis G, Zissel G, Muller-Quernheim J, Prasse A Macrophage activation in acute exacerbation of idiopathic pulmonary fibrosis. PLoS ONE, 2015-01-15;10(1):e0116775. 2015-01-15 [PMID: 25590613] (Human)
• Maddur M, Sharma M, Hegde P, Stephen-Victor E, Pulendran B, Kaveri S, Bayry J Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand. Nat Commun, 2014-06-09;5(0):4092. 2014-06-09 [PMID: 24910129] (Human)
• Parola C, Salogni L, Vaira X, Scutera S, Somma P, Salvi V, Musso T, Tabbia G, Bardessono M, Pasquali C, Mantovani A, Sozzani S, Bosisio D Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway. PLoS ONE, 2013-12-30;8(12):e82867. 2013-12-30 [PMID: 24386121] (Human)
• Zimmer A, Luce S, Gaignier F, Nony E, Naveau M, Biola-Vidamment A, Pallardy M, Van Overtvelt L, Mascarell L, Moingeon P Identification of a New Phenotype of Tolerogenic Human Dendritic Cells Induced by Fungal Proteases from Aspergillus oryzae. J. Immunol., 2011-03-02;186(7):3966-76. 2011-03-02 [PMID: 21368225] (Human)
• Krausgruber T, Blazek K, Smallie T IRF5 promotes inflammatory macrophage polarization and T(H)1-T(H)17 responses. Nat. Immunol., 2011-01-16;12(3):231-8. 2011-01-16 [PMID: 21240265] (Human)
• Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A Divergent effects of hypoxia on dendritic cell functions. Blood, 2008-08-11;112(9):3723-34. 2008-08-11 [PMID: 18694997] (Human)
• Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood, 2007-09-11;110(13):4319-30. 2007-09-11 [PMID: 17848619] (Human)
• Chang Y, Senechal S, de Nadai P, Chenivesse C, Gilet J, Vorng H, Legendre B, Tonnel AB, Wallaert B, Lassalle P, Tsicopoulos A Diesel exhaust exposure favors TH2 cell recruitment in nonatopic subjects by differentially regulating chemokine production. J. Allergy Clin. Immunol., 2006-06-21;118(2):354-60. 2006-06-21 [PMID: 16890758] (Human)
• Walker J, Tough DF Modification of TLR-induced activation of human dendritic cells by type I IFN: synergistic interaction with TLR4 but not TLR3 agonists. Eur. J. Immunol., 2006-07-01;36(7):1827-36. 2006-07-01 [PMID: 16783851] (Human)
• Merck E, Gaillard C, Scuiller M, Scapini P, Cassatella MA, Trinchieri G, Bates EE Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils. J. Immunol., 2006-03-01;176(5):3149-56. 2006-03-01 [PMID: 16493074] (Human)
• Gunther C, Bello-Fernandez C, Kopp T, Kund J, Carballido-Perrig N, Hinteregger S, Fassl S, Schwarzler C, Lametschwandtner G, Stingl G, Biedermann T, Carballido JM CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. J. Immunol., 2005-02-01;174(3):1723-8. 2005-02-01 [PMID: 15661937] (Human)

Bioinformatics

• Gene Symbol: CCL22