Human beta 2-Microglobulin Parameter Assay Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human beta 2-Microglobulin Parameter Assay Kit Summary

• Background: The Parameter beta 2-Microglobulin Immunoassay is a 1.5 hour forward sequential competitive enzyme immunoassay designed to measure beta 2M in serum, plasma, and urine.
• Specificity: Measures Human beta 2M levels in various samples.
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human beta 2-Microglobulin Parameter Assay Kit

• B2M
• beta 2Microglobulin
• beta 2-Microglobulin
• beta chain of MHC class I molecules
• beta-2-microglobin
• beta-2-microglobulin

Background

beta 2-Microglobulin (B2M) forms the light chain of Class I MHC molecules. It has been measured in a variety of body fluids, including serum/plasma, saliva, CSF, and urine. B2M freely passes through the glomerular membrane, but it is nearly completely reabsorbed and degraded in proximal tubule cells. Clinically, serum B2M is elevated in rheumatoid arthritis, systemic lupus erythematosus, viral infections, and conditions associated with decreased glomerular filtration.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for beta 2-Microglobulin (KGE019)(5)

Publications using KGE019

• SK Heo, EK Noh, YJ Lee, Y Shin, Y Kim, HS Im, H Kim, SJ Koh, YJ Min, JC Jo, Y Choi The soluble VCAM-1 level is a potential biomarker predicting severe acute graft versus host disease after allogeneic hematopoietic cell transplantation BMC Cancer, 2022-09-20;22(1):997. 2022-09-20 [PMID: 36127634] (Human)
• R Shaw, AE Lokshin, MC Miller, G Messerlian, RG Moore Stacking Machine Learning Algorithms for Biomarker-Based Preoperative Diagnosis of a Pelvic Mass Cancers, 2022-03-02;14(5):. 2022-03-02 [PMID: 35267599] (Human)
• E Latoch, K Kono?czuk, K Taranta-Ja, K Muszy?ska-, M Sawicka, A Wasilewska, M Krawczuk-R Urinary Beta-2-Microglobulin and Late Nephrotoxicity in Childhood Cancer Survivors Journal of Clinical Medicine, 2021-11-13;10(22):. 2021-11-13 [PMID: 34830560] (Human)
• A Sitlinger, MA Deal, E Garcia, DK Thompson, T Stewart, GA MacDonald, N Devos, D Corcoran, JS Staats, J Enzor, KJ Weinhold, DM Brander, JB Weinberg, DB Bartlett Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL) Cells, 2021-05-11;10(5):. 2021-05-11 [PMID: 34064804] (Human)
• RG Moore, A Blackman, MC Miller, K Robison, PA DiSilvestr, EE Eklund, R Strongin, G Messerlian Multiple biomarker algorithms to predict epithelial ovarian cancer in women with a pelvic mass: Can additional makers improve performance? Gynecol. Oncol., 2019-04-13;0(0):. 2019-04-13 [PMID: 30992143] (Human)

FAQs for beta 2-Microglobulin (KGE019). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.