Human ADAM12 Quantikine ELISA Kit

• Reactivity: Hu
• Applications: ELISA
• Conjugate: HRP

Human ADAM12 Quantikine ELISA Kit Summary

• Background: The Quantikine Human ADAM12 immunoassay is a 4.5 hour solid phase ELISA designed to measure human ADAM12 in cell culture supernates, serum, plasma, and urine. It contains CHO cell-expressed recombinant human ADAM12 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural ADAM12 showed linear curves that were parallel to the standard curves obtained u...sing the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring ADAM12.
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• Specificity: Natural and recombinant human ADAM12. This kit recognizes pro-ADAM12, mature ADAM12, and ADAM12/TIMP-3 complex.
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: ADAM12

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human ADAM12 Quantikine ELISA Kit

• a disintegrin and metalloproteinase domain 12 (meltrin alpha)
• ADAM 12
• ADAM metallopeptidase domain 12
• ADAM12
• disintegrin and metalloproteinase domain-containing protein 12
• EC 3.4.24
• EC 3.4.24.58
• MCMP
• MCMPMltna
• Meltrin alpha
• meltrin-alpha
• MLTNA
• MLTNEC 3.4.24.-

Background

Members of the ADAM or MDC (Metalloprotease, Disintegrin, Cysteine-rich) family contain pro, metalloprotease-like, disintegrin-like, cysteine-rich, transmembrane and cytoplasmic domains. They play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. Over 30 members have been identified and about half of them are active metalloproteases such as ADAM8, 9, 10, 12 and 17/TACE.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for ADAM12 (DAD120)(3)

Publications using DAD120

• JJ Zhang, CX Cao, LL Wan, W Zhang, ZJ Liu, JL Wang, Q Guo, H Tang Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway World Journal of Gastroenterology, 2022;28(17):1781-1797. 2022 [PMID: 35633908] (Human)
• T Shimura, D Dayde, H Wang, Y Okuda, H Iwasaki, M Ebi, M Kitagawa, T Yamada, T Yamada, SM Hanash, A Taguchi, H Kataoka Novel urinary protein biomarker panel for early diagnosis of gastric cancer Br. J. Cancer, 2020;0(0):. 2020 [PMID: 32934343] (Human)
• Horne AW, Brown JK, Tong S, Kaitu'u-Lino T Evaluation of ADAM-12 as a Diagnostic Biomarker of Ectopic Pregnancy in Women with a Pregnancy of Unknown Location. PLoS ONE, 2012;7(8):e41442. 2012 [PMID: 22927907] (Human)

Bioinformatics

• Gene Symbol: ADAM12