HSP90 Antibody (2D12)


Western Blot: Hsp90 Antibody (2D12) [NBP1-97450] - Analysis of human HeLa cell lysate, probed with HSP90 mAb (2D12).

Product Details

Reactivity Hu, Mu, Rt, Bv, Ca, Ch, Fi, Fu, GP, Ha, Pm, Rb, ShSpecies Glossary
Applications WB, IP
Please see the vial label for concentration. If unlisted please contact technical services.

Order Details

HSP90 Antibody (2D12) Summary

Native mouse Hsp90.
Ammonium sulfate precipitation
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
Liquid. In PBS, pH 7.2, containing 50% glycerol
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Ammonium sulfate precipitation


Application Notes
This antibody is useful in Immunoprecipitation and detects a band of ~90kDa by Western blot.
Read Publications using
NBP1-97450 in the following applications:

  • IP
    3 publications
  • WB
    2 publications

Reactivity Notes

Human, Mouse, Rat, Beluga, Bovine, Canine, Chicken, Fish, Guinea Pig, Hamster, Primate, Rabbit, Sheep, and water mold.

Alternate Names for HSP90 Antibody (2D12)

  • FLJ31884
  • Heat shock 86 kDa
  • heat shock 90kD protein 1, alpha
  • heat shock 90kD protein 1, alpha-like 4
  • heat shock 90kD protein, alpha-like 4
  • heat shock 90kDa protein 1, alpha
  • heat shock protein 90kDa alpha (cytosolic), class A member 1
  • heat shock protein HSP 90-alpha
  • Hsp89
  • Hsp90
  • HSP90AHSP86
  • HSP90N
  • HSPC1HSP 86
  • HSPN
  • LAP2
  • Renal carcinoma antigen NY-REN-38


The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: WB, ELISA, IHC, IHC-P, IP, S-ELISA
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Species: Hu, Mu, Rt, Bv, Ca, Ch, Fi, Fu, GP, Ha, Pm, Rb, Sh
Applications: WB, IP

Publications for HSP90 Antibody (NBP1-97450)(4)

Reviews for HSP90 Antibody (NBP1-97450) (0)

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for HSP90 Antibody (NBP1-97450) (0)

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Secondary Antibodies


Isotype Controls

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HSP90 NBP1-97450

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Blogs on HSP90.

HSP90 - an essential eukaryotic protein with implications for drug development
The heat-shock protein 90 (HSP90) family is a group of highly conserved molecular chaperones with important functions in protein folding and in signal transduction. The HSP90 protein structure is so well conserved that some HSP90 antibodies are rea...  Read full blog post.

Integrin beta 1 binding protein 2
ITGB1BP2 is a muscle-specific protein cloned by a rat created by Branccio's group in Italy that was found to interact with the cytoplasmic domain of integrin beta 11. It is expressed only in heart and skeletal muscle but is not essential for normal de...  Read full blog post.

HSP Antibodies: Novel Therapies for MMP-induced Metastatic Breast Cancer
The matrix metalloproteinases are zinc-dependent protease enzymes which interact with a range of ECM (extracellular matrix) proteins, and are activated by proteolytic cleavage. We at Novus Biologicals offer a wide range of top quality MMP reagents, in...  Read full blog post.

Heat Shock Proteins: An Overview
Heat Shock Proteins (HSPs) are a ubiquitous group of molecular chaperone proteins that have evolved unique mechanisms, within their host cells, to facilitate survival in hostile environments such as heat, oxidative (hypoxia), pH and cold. Under permis...  Read full blog post.

The Heat is On: Heat Shock Proteins and the Link to Cancer
Novus Biologicals offers an extensive antibody catalog targeting heat shock proteins (HSPs). A large protein group covering a number of families, the HSPs are functionally related by their dramatic upregulation in response to stress. Stress triggers m...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol HSP90AA1

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