Hu, Mu, Rt, Po, Ba, Ca, Ch, Fi, Gp, Pm, Rb, ShApplications:
WB, Flow, Flow-IC, ICC/IF, IHC, IHC-PHost:
Hu, Mu, RtApplications:
WB, ICC/IF, IHC, IHC-PHost:
Hu, Mu, Rt, PlApplications:
WB, ELISA, EM, ICC/IF, IHC, IHC-P, IPHost:
Hsp90 has at least 2 isoforms, Hsp90a and Hsp90b which are encoded by separate genes. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cells powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steroid receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90. It has been suggested that Hsp90 acts as a capacitor for morphological evolution by buffering widespread variation, which may affect morphogenic pathways.
|Product By Gene ID
- heat shock protein HSP 90-alpha
- Heat shock 86 kDa
- heat shock 90kD protein, alpha-like 4
- heat shock 90kDa protein 1, alpha
- heat shock 90kD protein 1, alpha-like 4
- heat shock 90kD protein 1, alpha
- HSPC1HSP 86
- Renal carcinoma antigen NY-REN-38
- heat shock protein 90kDa alpha (cytosolic), class A member 1
Bioinformatics Tool for HSP90
Discover related pathways, diseases and genes to HSP90. Need help? Read the Bioinformatics Tool Guide
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Related HSP90 Blog Posts
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|HSP90 - an essential eukaryotic protein with implications for drug development
The heat-shock protein 90 (HSP90) family is a group of highly conserved molecular chaperones with important functions in protein folding and in signal transduction. The HSP90 protein structure is so well conserved that some HSP90 antibodies are rea... Read more.
|Integrin beta 1 binding protein 2
ITGB1BP2 is a muscle-specific protein cloned by a rat created by Branccio's group in Italy that was found to interact with the cytoplasmic domain of integrin beta 11. It is expressed only in heart and skeletal muscle but is not essential for normal de... Read more.
|HSP Antibodies: Novel Therapies for MMP-induced Metastatic Breast Cancer
The matrix metalloproteinases are zinc-dependent protease enzymes which interact with a range of ECM (extracellular matrix) proteins, and are activated by proteolytic cleavage. We at Novus Biologicals offer a wide range of top quality MMP reagents, in... Read more.
|Heat Shock Proteins: An Overview
Heat Shock Proteins (HSPs) are a ubiquitous group of molecular chaperone proteins that have evolved unique mechanisms, within their host cells, to facilitate survival in hostile environments such as heat, oxidative (hypoxia), pH and cold. Under permis... Read more.
|The Heat is On: Heat Shock Proteins and the Link to Cancer
Novus Biologicals offers an extensive antibody catalog targeting heat shock proteins (HSPs). A large protein group covering a number of families, the HSPs are functionally related by their dramatic upregulation in response to stress. Stress triggers m... Read more.