HSH2D Antibody

Product Discontinued

HSH2D Antibody Summary

• Immunogen: Peptide with sequence C-EHQGLAEPENDQLPE corresponding to internal region according to NP_116244.1.
• Epitope: C-EHQGLAEPENDQLPE
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: HSH2D
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:2000
• Application Notes: WB: Preliminary experiments in human spleen, tonsil, and lymph node lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for HSH2D Antibody

• Adaptor in lymphocytes of unknown function X
• ALXHematopoietic SH2 protein
• FLJ14886
• hematopoietic SH2 domain containing
• hematopoietic SH2 domain-containing protein
• HSH2

Background

T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HSH2D Antibody (NBP1-52156)(1)

Publication using NBP1-52156

• Shapiro MJ, Chen YY, Shapiro VS. The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation. J Biol Chem 2005-11-01 [PMID: 16169852]

Bioinformatics

• Gene Symbol: HSH2D
• Entrez:
  • 84941(Human)
• Uniprot:
  • NP_116244.1(Human)