HLA-DR Antibody (37.68)

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Product Details

Summary
Reactivity Hu, Bv, Gt, ShSpecies Glossary
Applications Flow, IHC, IHC-Fr, IP
Clone
37.68
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

HLA-DR Antibody (37.68) Summary

Immunogen
Splenocytes from ATL mice (1)
Specificity
NB100-65424 recognizes a monomorphic epitope on ovine MHC class II DR molecules. The distribution of ovine DR molecules on T lymphocytes has been shown to vary with immune status and age. Initially T lymphocytes lack class II molecules, then T lymphocytes progressively express DR molecules.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
HLA-DRA
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation 1:10-1:500

Reactivity Notes

Reacts with Sheep. Cross reacts with Goat, Human and Bovine.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for HLA-DR Antibody (37.68)

  • FLJ51114
  • histocompatibility antigen HLA-DR alpha
  • HLA class II histocompatibility antigen, DR alpha chain
  • HLADR
  • HLA-DR
  • HLA-DRA
  • HLA-DRA1
  • major histocompatibility complex, class II, DR alpha
  • MHC cell surface glycoprotein
  • MHC class II antigen DRA
  • MHC Class II DR
  • MLRW

Background

MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for HLA-DR Antibody (NB100-65424) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-65424AF405
Alexa Fluor 488 Labeled NB100-65424AF488
Alexa Fluor 647 Labeled NB100-65424AF647
Alexa Fluor 700 Labeled NB100-65424AF700
Allophycocyanin Labeled NB100-65424APC
DyLight 350 Labeled NB100-65424UV
DyLight 405 Labeled NB100-65424V
DyLight 488 Labeled NB100-65424G
DyLight 680 Labeled NB100-65424FR
DyLight 755 Labeled NB100-65424IR
PE Labeled NB100-65424PE
PerCP Labeled NB100-65424PCP

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HLA-DR NB100-65424

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Bioinformatics

Gene Symbol HLA-DRA
Entrez