Hepcidin Antimicrobial Peptide Antibody (JA11-27)

Immunohistochemistry-Paraffin: Hepcidin Antimicrobial Peptide Antibody (JA11-27) [NBP2-66886] - Analysis of paraffin-embedded rat heart tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: Hepcidin Antimicrobial Peptide Antibody (JA11-27) [NBP2-66886] - Analysis of paraffin-embedded human liver tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: Hepcidin Antimicrobial Peptide Antibody (JA11-27) [NBP2-66886] - Analysis of paraffin-embedded rat brain tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.

Product Discontinued

Hepcidin Antimicrobial Peptide Antibody (JA11-27) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Recombinant protein within Hepcidin Antimicrobial Peptide aa 1-84 / 84. (SwissProt: P81172 Human)
• Localization: Secreted.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: HAMP
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: TBS (pH7.4), 0.05% BSA, 40% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Hepcidin Antimicrobial Peptide Antibody (JA11-27)

• HAMP
• HEPC
• hepcidin antimicrobial peptide
• Hepcidin
• HEPCPutative liver tumor regressor
• HFE2B
• HFE2Bhepcidin
• LEAP1
• LEAP-1
• LEAP1PLTR
• Liver-expressed antimicrobial peptide 1
• PLTR

Background

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HAMP