Hematopoietic Prostaglandin D Synthase/HPGDS Antibody (735301) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clone: 735301
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Hematopoietic Prostaglandin D Synthase/HPGDS Antibody (735301) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human Hematopoietic Prostaglandin D Synthase/HPGDS
  Pro2-Leu199
  Accession # O60760
• Specificity: Detects human Hematopoietic Prostaglandin D Synthase/HPGDS in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Hematopoietic Prostaglandin D Synthase/HPGDS Antibody (735301) [Alexa Fluor® 350]

• EC 2.5.1.18
• EC 5.3.99.2
• glutathione S-transferase sigma
• Glutathione S-transferase
• Glutathione-dependent PGD synthase
• Glutathione-requiring prostaglandin D synthase
• GST class-sigma
• GSTS
• GSTShematopoietic prostaglandin D2 synthase
• hematopoietic prostaglandin D synthase
• HPGDS
• H-PGDS
• PGDS
• PGDSglutathione-dependent PGD synthetase
• Prostaglandin-H2 D-isomerase
• PTGDS2

Background

Prostaglandin D Synthase (PGDS) catalyzes the conversion of prostaglandin (PG) H₂ to PGD₂, which is a major prostanoid produced in a variety of tissues. Two types of PGDS have been isolated; the glutathione-dependent hematopoietic PGDS (HPGDS) and the glutathione-independent lipocalin‑type PGDS (1). HPGDS is a cytosolic enzyme that is expressed in mast cells and antigen presenting cells (2, 3). It is the only mammalian member of the class Sigma glutathione S‑transferase, showing a broad specificity towards standard transferase substrates (4). The PGD₂ produced by HPGDS is involved in many physiological processes such as maintaining body temperature, promotion of sleep, inhibition of platelet aggregation and bronchoconstriction (5). It also functions in immune response and acts as a mediator in allergy and inflammation (6). HPGDS‑specific inhibitors may be therapeutically useful anti‑allergic and anti‑inflammatory drugs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • O60760()