HAAO Antibody - BSA Free

Western Blot: HAAO Antibody - BSA Free [NBP3-46151] - Human liver tissue were subjected to SDS PAGE followed by western blot with (HAAO antibody) at dilution of 1:300

Immunohistochemistry: HAAO Antibody - BSA Free [NBP3-46151] - Immunohistochemistry of paraffin-embedded human gliomas using (HAAO antibody) at dilution of 1:100

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

HAAO Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit HAAO Antibody - BSA Free (NBP3-46151) is a polyclonal antibody validated for use in IHC, WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: 3-hydroxyanthranilate 3,4-dioxygenase. (Uniprot# P46952)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HAAO
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 1:20-1:200
  • Western Blot 1:500-1:2000
• Theoretical MW: 33 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS, 50% Glycerol, pH (7.3)
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for HAAO Antibody - BSA Free

• 3-HAO
• 3-hydroxyanthranilate 3,4-dioxygenase
• 3-hydroxyanthranilic acid dioxygenase
• EC 1.13.11.6,3-hydroxyanthranilate oxygenase
• HAD
• HAO

Background

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HAAO