HAAO Products

Description

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq]

Bioinformatics

Entrez	23498 Human
Uniprot	AAH29510 Human AAH29510.1 Human NM_012205 Human P46952 Human
Product By Gene ID	23498
Alternate Names	3-HAO 3-hydroxyanthranilate 3,4-dioxygenase 3-hydroxyanthranilic acid dioxygenase EC 1.13.11.6,3-hydroxyanthranilate oxygenase HAD HAO

Research Areas for HAAO

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Lipid and Metabolism