Growth Hormone Antibody

Product Discontinued

Growth Hormone Antibody Summary

• Immunogen: The antibody reacts with the Growth Hormone antigen.
• Specificity: The Growth Hormone antibody can be used for the diagnosis of tumors of the pituitary.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GH1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
• Application Notes: Detection of growth hormone producing cells.The antibody can be used on frozen sections and on paraffin embedded tissue, no pretreatment is necessary. Use as positive control pituitary gland. Dilute approximately 1:50, based on the indirect method, with a normal ABC method the dilution can be 5-10 times higher, but the optimal dilution should be tested by serial dilution) Dilute immediately before use with PBS or Tris.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Diluted whole antisera
• Preservative: 0.02% Sodium Azide
• Purity: Unpurified

Alternate Names for Growth Hormone Antibody

• GH1
• GHB5
• GHIGHD1B
• GHN
• GH-N
• GHNGrowth hormone
• GH-Nsomatotropin
• growth hormone 1Pituitary growth hormone
• Growth Hormone
• hGH-N
• IGHD1A
• IGHD2
• Somatotropin

Background

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GH1
• Entrez:
  • 2688(Human)
  • 396884(Porcine)
• Uniprot:
  • P01241(Human)