GRIM19 Antibody

Product Discontinued

GRIM19 Antibody Summary

• Immunogen: Synthetic peptide to human GRIM-19 (QAETDRRTLQMLRE).
• Specificity: Reacts with the human and mouse GRIM-19 protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NDUFA13
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000
• Application Notes: Western blot- Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.
• Control:

  GRIM19 Overexpression Lysate

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for GRIM19 Antibody

• B16.6
• CDA016
• Cell death regulatory protein GRIM-19
• cell death-regulatory protein GRIM19
• CI-B16.6
• complex I B16.6 subunit
• Complex I-B16.6
• FLJ58045
• FLJ59191
• Gene associated with retinoic and IFN-induced mortality 19 protein
• Gene associated with retinoic and interferon-induced mortality 19 protein
• GRIM-19CGI-39
• GRIM19NADH-ubiquinone oxidoreductase B16.6 subunit
• NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Background

A novel gene, Genes associated with Retinoid-IFN-induced Mortality (GRIM) GRIM-19 gene was identified. Antisense expression of GRIM-19 confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM-19 protein. Overexpression of GRIM-19 enhances cell death in response to IFN/RA. GRIM-19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM-19 is a novel cell death-regulatory molecule.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NDUFA13
• Entrez:
  • 51079(Human)
  • 67184(Mouse)