GRIM19 Antibody

Product Discontinued

GRIM19 Antibody Summary

• Immunogen: Synthetic peptide: C-RTTEEALHASH, representing the C Terminus of the human protein according to NP_057049.3
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NDUFA13
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA 1:32000
• Application Notes: Peptide ELISA: antibody detection limit dilution 1:32000. Western Blot: Preliminary experiments in Human Heart, Skeletal Muscle and Placenta lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates?
• Control:

  GRIM19 Overexpression Lysate

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for GRIM19 Antibody

• B16.6
• CDA016
• Cell death regulatory protein GRIM-19
• cell death-regulatory protein GRIM19
• CI-B16.6
• complex I B16.6 subunit
• Complex I-B16.6
• FLJ58045
• FLJ59191
• Gene associated with retinoic and IFN-induced mortality 19 protein
• Gene associated with retinoic and interferon-induced mortality 19 protein
• GRIM-19CGI-39
• GRIM19NADH-ubiquinone oxidoreductase B16.6 subunit
• NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Background

A novel gene, Genes associated with Retinoid IFN induced Mortality (GRIM) GRIM19 gene was identified. Antisense expression of GRIM19 confers a strong resistance against IFN/RA induced death by reducing the intracellular levels of GRIM19 protein. Overexpression of GRIM19 enhances cell death in response to IFN/RA. GRIM19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM19 is a novel cell death regulatory molecule. Antisense expression of GRIM 19 (Genes associated with Retinoid-IFN-induced Mortality) confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM 19 protein. Overexpression of GRIM 19 enhances cell death in response to IFN/RA. GRIM 19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM 19 is a novel cell death-regulatory molecule.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NDUFA13
• Entrez:
  • 51079(Human)
• Uniprot:
  • NP_057049.3(Human)