GRID2 Antibody Blocking Peptide

Product Discontinued

GRID2 Antibody Blocking Peptide Summary

• Description: A GRID2 antibody blocking peptide.
• Specificity: A synthetic peptide from c-terminal region of human GRID2 (Glutamate receptor delta-2 subunit) conjugated to an immunogenic carrier protein was used as the antigen.
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: GRID2
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-46489.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Purity: Unpurified

Alternate Names for GRID2 Antibody Blocking Peptide

• B230104L07Rik
• cpr
• creeper
• gluR delta-2 subunit
• GLURD2
• GluRdelta2
• glutamate receptor delta-2 subunit
• glutamate receptor, ionotropic, delta 2
• GRID2
• ho
• hotfoot
• Lc
• lurcher
• minisatellite 10ac detected by probe MMS10
• MMS10-AC
• Ms10ac
• nmf408
• SCAR18
• tpr

Background

Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: GRID2