GPR119 Antibody [DyLight 550]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 550

GPR119 Antibody [DyLight 550] Summary

Immunogen
A synthetic peptide made to an internal region of the human GPR119 protein (within residues 150-250). [Swiss-Prot Q8TDV5]
Localization
Cell membrane; Multi-pass membrane protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GPR119
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:50
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Paraffin 1:100
Application Notes
This GPR119 antibody is useful for Immunohistochemistry paraffin embedded sections and Immunocytochemistry/Immunofluorescence. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human and mouse. Immunogen sequence has 88% identity to rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for GPR119 Antibody [DyLight 550]

  • G protein-coupled receptor 119
  • glucose-dependent insulinotropic receptor
  • GPCR2
  • GPR119
  • G-protein coupled receptor 119
  • G-protein coupled receptor 2
  • hGPCR2
  • MGC119957

Background

The G-protein-coupled receptor 119 is important in type II diabetes. It is expressed primarily in the pancreas and gastrointestinal tract. When GPR119 is activated in gut cells, it leads to insulin secretion from pancreatic beta cells. This insulin secretion is glucose-dependent and leads to the release of GLP1, GIP, and PYY, which are known to help regulate the diabetic response to dietary effects. GPR119 also is important in gut inflammation pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GPR119
Entrez